Myeloid Sarcoma in a One-Month-Old Infant

• Main Authors: Chihiro Wakusawa, Taku Fujimura, Akira Hashimoto, Setsuya Aiba
• Format: Article
• Language: English
• Published: Karger Publishers 2011-09-01
• Series: Case Reports in Dermatology
• Subjects: Myeloid sarcoma; CD4; Hematopoietic neoplasm
• Online Access: http://www.karger.com/Article/FullText/333206

Myeloid sarcoma, which sometimes accompanies recurrent systemic leukemia, is a rare manifestation of congenital leukemia. We describe the case of a 1-month-old Japanese girl with myeloid sarcoma, who did not fulfill the criteria of systemic leukemia. The physical examination revealed a bruise-like plaque on the right side of her chest. Histopathologically, there were CD4+ CD56– CD68+ atypical large lymphocytes densely infiltrating the upper dermis and the subcutaneous tissue. Biopsy specimens from bone marrow contained only 3.4% of blast cells, showing an abnormality of the mixed-lineage leukemia gene. The skin lesions disappeared 10 days after chemotherapy, and there was no recurrence for one and a half years.