Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders
Background and Objective: Tau-specific positron emission topography (PET) imaging enables in vivo assessment of Alzheimer's disease (AD). We aimed to investigate its performance in combination with plasma tau levels in patients with non-AD tauopathy.Methods: A total of 47 participants were enro...
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doaj-d79f6e1513b249fcbc678d0b0caade652021-03-29T04:55:50ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-03-011310.3389/fnagi.2021.646440646440Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative DisordersCheng-Hsuan Li0Cheng-Hsuan Li1Ta-Fu Chen2Ming-Jang Chiu3Ming-Jang Chiu4Ming-Jang Chiu5Ming-Jang Chiu6Ruoh-Fang Yen7Ming-Chieh Shih8Chin-Hsien Lin9Department of Neurology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Neurology, National Taiwan University Biomedical Park Hospital, Hsinchu, TaiwanDepartment of Neurology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Neurology, National Taiwan University Hospital, Taipei, TaiwanGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Biomedical Engineering and Bioinformatics, National Taiwan University, Taipei, TaiwanGraduate Institute of Psychology, National Taiwan University, Taipei, TaiwanDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanDepartment of Neurology, National Taiwan University Hospital, Taipei, TaiwanBackground and Objective: Tau-specific positron emission topography (PET) imaging enables in vivo assessment of Alzheimer's disease (AD). We aimed to investigate its performance in combination with plasma tau levels in patients with non-AD tauopathy.Methods: A total of 47 participants were enrolled, including 10 healthy controls, 16 with tauopathy parkinsonism syndromes (9 with corticobasal syndrome [CBS], 7 with progressive supranuclear palsy [PSP]), 9 with frontotemporal dementia (FTD), 4 with AD, and 8 with Parkinson's disease (PD). All participants underwent clinical assessments, 18F-T807 tau PET, brain MRI, and plasma tau assay.Results: The global cortical standard uptake value ratio (SUVR) of 18F-T807 PET was comparable between PD and control (p = 0.088). The cortical SUVR was significantly higher in AD group (p = 0.002) but was modestly increased in PSP group compared to the PD group (p = 0.044), especially in parietal and pallidal regions. Asymmetric 18F-T807 uptake at the pallidum was noted in patients with CBS and FTD. Cortical tau tracer uptake was associated with increased plasma total tau level (p = 0.016), especially in frontal and parietal regions. Regional tracer uptake was correlated with cortical thinning in patients with CBS and PSP (CBS: r = −0.092, p = 0.025; PSP: r = −0.114, p = 0.015).Conclusions: The 18F-T807 tau tracer uptake was only modestly increased in patients with PSP. Although the cortical tau tracer uptake correlated with regional cortical atrophy and plasma tau levels, a four-repeated tau-specific tracer is needed for future classifying tauopathy parkinsonism syndromes.https://www.frontiersin.org/articles/10.3389/fnagi.2021.646440/fulltauopathiesTau PETbiomarker18F-T807progressive supranuclear palsy (PSP)corticobasal syndrome (CBS) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng-Hsuan Li Cheng-Hsuan Li Ta-Fu Chen Ming-Jang Chiu Ming-Jang Chiu Ming-Jang Chiu Ming-Jang Chiu Ruoh-Fang Yen Ming-Chieh Shih Chin-Hsien Lin |
spellingShingle |
Cheng-Hsuan Li Cheng-Hsuan Li Ta-Fu Chen Ming-Jang Chiu Ming-Jang Chiu Ming-Jang Chiu Ming-Jang Chiu Ruoh-Fang Yen Ming-Chieh Shih Chin-Hsien Lin Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders Frontiers in Aging Neuroscience tauopathies Tau PET biomarker 18F-T807 progressive supranuclear palsy (PSP) corticobasal syndrome (CBS) |
author_facet |
Cheng-Hsuan Li Cheng-Hsuan Li Ta-Fu Chen Ming-Jang Chiu Ming-Jang Chiu Ming-Jang Chiu Ming-Jang Chiu Ruoh-Fang Yen Ming-Chieh Shih Chin-Hsien Lin |
author_sort |
Cheng-Hsuan Li |
title |
Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders |
title_short |
Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders |
title_full |
Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders |
title_fullStr |
Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders |
title_full_unstemmed |
Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders |
title_sort |
integrated 18f-t807 tau pet, structural mri, and plasma tau in tauopathy neurodegenerative disorders |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-03-01 |
description |
Background and Objective: Tau-specific positron emission topography (PET) imaging enables in vivo assessment of Alzheimer's disease (AD). We aimed to investigate its performance in combination with plasma tau levels in patients with non-AD tauopathy.Methods: A total of 47 participants were enrolled, including 10 healthy controls, 16 with tauopathy parkinsonism syndromes (9 with corticobasal syndrome [CBS], 7 with progressive supranuclear palsy [PSP]), 9 with frontotemporal dementia (FTD), 4 with AD, and 8 with Parkinson's disease (PD). All participants underwent clinical assessments, 18F-T807 tau PET, brain MRI, and plasma tau assay.Results: The global cortical standard uptake value ratio (SUVR) of 18F-T807 PET was comparable between PD and control (p = 0.088). The cortical SUVR was significantly higher in AD group (p = 0.002) but was modestly increased in PSP group compared to the PD group (p = 0.044), especially in parietal and pallidal regions. Asymmetric 18F-T807 uptake at the pallidum was noted in patients with CBS and FTD. Cortical tau tracer uptake was associated with increased plasma total tau level (p = 0.016), especially in frontal and parietal regions. Regional tracer uptake was correlated with cortical thinning in patients with CBS and PSP (CBS: r = −0.092, p = 0.025; PSP: r = −0.114, p = 0.015).Conclusions: The 18F-T807 tau tracer uptake was only modestly increased in patients with PSP. Although the cortical tau tracer uptake correlated with regional cortical atrophy and plasma tau levels, a four-repeated tau-specific tracer is needed for future classifying tauopathy parkinsonism syndromes. |
topic |
tauopathies Tau PET biomarker 18F-T807 progressive supranuclear palsy (PSP) corticobasal syndrome (CBS) |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.646440/full |
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