Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study
Background: We aimed to compare the efficacy of tamsulosin 0.4 mg once a day alone and the combination therapy involving tamsulosin 0.4 mg once a day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsic...
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PAGEPress Publications
2020-10-01
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Series: | Archivio Italiano di Urologia e Andrologia |
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Online Access: | https://www.pagepressjournals.org/index.php/aiua/article/view/8908 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ferdinando Fusco Massimiliano Creta Francesco Trama Fabio Esposito Felice Crocetto Achille Aveta Francesco Mangiapia Ciro Imbimbo Marco Capece Roberto La Rocca Vincenzo Mirone Nicola Longo |
spellingShingle |
Ferdinando Fusco Massimiliano Creta Francesco Trama Fabio Esposito Felice Crocetto Achille Aveta Francesco Mangiapia Ciro Imbimbo Marco Capece Roberto La Rocca Vincenzo Mirone Nicola Longo Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study Archivio Italiano di Urologia e Andrologia Benign prostatic hyperplasia; Combination therapy; Lower urinary tract symptoms; Phytotherapy |
author_facet |
Ferdinando Fusco Massimiliano Creta Francesco Trama Fabio Esposito Felice Crocetto Achille Aveta Francesco Mangiapia Ciro Imbimbo Marco Capece Roberto La Rocca Vincenzo Mirone Nicola Longo |
author_sort |
Ferdinando Fusco |
title |
Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study |
title_short |
Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study |
title_full |
Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study |
title_fullStr |
Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study |
title_full_unstemmed |
Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study |
title_sort |
tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results from a retrospective comparative study |
publisher |
PAGEPress Publications |
series |
Archivio Italiano di Urologia e Andrologia |
issn |
1124-3562 2282-4197 |
publishDate |
2020-10-01 |
description |
Background: We aimed to compare the efficacy of tamsulosin 0.4 mg once a day alone and the combination therapy involving tamsulosin 0.4 mg once a day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid in patients with lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH).
Methods: We performed a retrospective matched paired comparison. The clinical records of LUTS/BPH patients who underwent medical therapy with tamsulosin 0.4 mg/day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid between January 2019 to September 2019 were reviewed (Group 1). These patients were compared in a 1:1 fashion with LUTS/BPH patients who underwent therapy with tamsulosin 0.4 mg/day alone (Group 2). Total, storage, voiding and Quality of Life (QoL) international prostate symptom (IPSS) score, as well as overactive bladder (OAB)-v8 score and treatment- related adverse events recorded at 40 days follow-up in both groups were compared.
Results: At 40 days follow-up mean total, storage, voiding and QoL IPSS sub-scores as well as OAB-v8 score significantly improved in both groups. Intergroup comparison showed statistically significant lower mean total IPSS score (11.6 vs 12.4, p = 0.04) mean storage IPSS sub-score (6.5 vs 7.5, p = 0.01), and mean OAB v8 score (16.7 vs 18.8, p = 0.03) in patients in the Group 1.
Conclusions: The combination of tamsulosin 0.4 mg/die plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid LGlutamine bid provides statistically significant advantages in terms of storage LUTS improvements in patients with LUTS/BPH compared to tamsulosin 0.4 mg/day alone. These findings are preliminary and further prospective studies on a greater number of patients are needed to confirm it.
|
topic |
Benign prostatic hyperplasia; Combination therapy; Lower urinary tract symptoms; Phytotherapy |
url |
https://www.pagepressjournals.org/index.php/aiua/article/view/8908 |
work_keys_str_mv |
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doaj-d7a03ea88c5e45ec9bada486fedaaa5e2020-11-25T02:47:53ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972020-10-0192310.4081/aiua.2020.3.173Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative studyFerdinando Fusco0Massimiliano Creta1Francesco Trama2Fabio Esposito3Felice Crocetto4Achille Aveta5Francesco Mangiapia6Ciro Imbimbo7Marco Capece8Roberto La Rocca9Vincenzo Mirone10Nicola Longo11Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. NaplesDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples Background: We aimed to compare the efficacy of tamsulosin 0.4 mg once a day alone and the combination therapy involving tamsulosin 0.4 mg once a day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid in patients with lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH). Methods: We performed a retrospective matched paired comparison. The clinical records of LUTS/BPH patients who underwent medical therapy with tamsulosin 0.4 mg/day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid between January 2019 to September 2019 were reviewed (Group 1). These patients were compared in a 1:1 fashion with LUTS/BPH patients who underwent therapy with tamsulosin 0.4 mg/day alone (Group 2). Total, storage, voiding and Quality of Life (QoL) international prostate symptom (IPSS) score, as well as overactive bladder (OAB)-v8 score and treatment- related adverse events recorded at 40 days follow-up in both groups were compared. Results: At 40 days follow-up mean total, storage, voiding and QoL IPSS sub-scores as well as OAB-v8 score significantly improved in both groups. Intergroup comparison showed statistically significant lower mean total IPSS score (11.6 vs 12.4, p = 0.04) mean storage IPSS sub-score (6.5 vs 7.5, p = 0.01), and mean OAB v8 score (16.7 vs 18.8, p = 0.03) in patients in the Group 1. Conclusions: The combination of tamsulosin 0.4 mg/die plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid LGlutamine bid provides statistically significant advantages in terms of storage LUTS improvements in patients with LUTS/BPH compared to tamsulosin 0.4 mg/day alone. These findings are preliminary and further prospective studies on a greater number of patients are needed to confirm it. https://www.pagepressjournals.org/index.php/aiua/article/view/8908Benign prostatic hyperplasia; Combination therapy; Lower urinary tract symptoms; Phytotherapy |