Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects
Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its engagement of pleiotropic signaling via its two receptors: TNFR1 and TNFR2. Extensive research has yielded mechani...
Main Authors: | Portia Gough, Ian A. Myles |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-11-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.585880/full |
Similar Items
-
TNF receptor associated factor 1 (TRAF1) is a major target of soluble TWEAK
by: José Antonio Carmona Arana, et al.
Published: (2014-02-01) -
Inhibitors of tumor necrosis factor-a and mechanisms of their action
by: Bufan Biljana, et al.
Published: (2020-01-01) -
Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily
by: Kirstin Kucka, et al.
Published: (2021-02-01) -
Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis
by: Thais Fontes Bessa, et al.
Published: (2012-12-01) -
Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis
by: Thais Fontes Bessa, et al.