A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil.

A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil.

Praziquantel at 40 mg/kg in a single dose is the WHO recommended treatment for all forms of schistosomiasis, but 60 mg/kg is also deployed nationally.Four trial sites in the Philippines, Mauritania, Tanzania and Brazil enrolled 856 patients using a common protocol, who were randomised to receive pra...

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Main Authors: Piero L Olliaro, Michel T Vaillant, Vincente J Belizario, Nicholas J S Lwambo, Mohamed Ouldabdallahi, Otavio S Pieri, Maria L Amarillo, Godfrey M Kaatano, Mamadou Diaw, Analucia C Domingues, Tereza C Favre, Olivier Lapujade, Fabiana Alves, Lester Chitsulo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3114749?pdf=render

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