Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration

Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration

The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growin...

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Main Authors: Bei Yin, Qingge Ma, Chenghao Song, Lingyi Zhao, Fanyuan Yu, Chenglin Wang, Yu Shi, Ling Ye
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2021/6696894
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spelling doaj-d7b4d3a3a4da4c9ca51607f2b8b246822021-02-15T12:53:12ZengHindawi LimitedStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66968946696894Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone RegenerationBei Yin0Qingge Ma1Chenghao Song2Lingyi Zhao3Fanyuan Yu4Chenglin Wang5Yu Shi6Ling Ye7State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaThe reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges.http://dx.doi.org/10.1155/2021/6696894
collection DOAJ
language English
format Article
sources DOAJ
author Bei Yin
Qingge Ma
Chenghao Song
Lingyi Zhao
Fanyuan Yu
Chenglin Wang
Yu Shi
Ling Ye
spellingShingle Bei Yin
Qingge Ma
Chenghao Song
Lingyi Zhao
Fanyuan Yu
Chenglin Wang
Yu Shi
Ling Ye
Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
Stem Cells International
author_facet Bei Yin
Qingge Ma
Chenghao Song
Lingyi Zhao
Fanyuan Yu
Chenglin Wang
Yu Shi
Ling Ye
author_sort Bei Yin
title Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
title_short Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
title_full Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
title_fullStr Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
title_full_unstemmed Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
title_sort exosome-derived noncoding rnas as a promising treatment of bone regeneration
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2021-01-01
description The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges.
url http://dx.doi.org/10.1155/2021/6696894
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