Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults
Objectives. Diagnostic markers of infection have had little innovation over the last few decades. CD64, a marker expressed on the surface of neutrophils, may have utility for this purpose. Methods. This study was conducted in an adult intensive care unit (ICU) in São Paulo, Brazil, with 89 patients....
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doaj-d7ba5f62709c4dab95548c1890697c352020-11-25T00:43:23ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/65932326593232Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill AdultsThiago Zinsly Sampaio Camargo0Alexandre R. Marra1Nydia Strachman Bacal2Eduardo Casaroto3Lilian Moreira Pinto4Jacyr Pasternak5Elivane da Silva Victor6Oscar Fernando Pavão dos Santos7Michael B. Edmond8Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilInstituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilClinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilIntensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilIntensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilClinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilInstituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilDivision of Medical Practice, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USAObjectives. Diagnostic markers of infection have had little innovation over the last few decades. CD64, a marker expressed on the surface of neutrophils, may have utility for this purpose. Methods. This study was conducted in an adult intensive care unit (ICU) in São Paulo, Brazil, with 89 patients. We evaluated CD64 in patients with documented or clinically diagnosed infection (infection group) and controls (patients without any evidence of infection) by two different methodologies: method #1, an in house assay, and method #2, the commercial kit Leuko64 (Trillium Diagnostics). Results. CD64 displayed good discriminating power with a 91.2% sensitivity (95% CI 90.7–91.6%) for detecting infection. The commercial kit (Leuko64) demonstrated higher specificity (87.3%) compared with method #1 as well as better accuracy (88.8%). Conclusions. CD64 seems to be a promising marker of infection in the intensive care setting, with Leuko64 showing a slight advantage.http://dx.doi.org/10.1155/2016/6593232 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thiago Zinsly Sampaio Camargo Alexandre R. Marra Nydia Strachman Bacal Eduardo Casaroto Lilian Moreira Pinto Jacyr Pasternak Elivane da Silva Victor Oscar Fernando Pavão dos Santos Michael B. Edmond |
spellingShingle |
Thiago Zinsly Sampaio Camargo Alexandre R. Marra Nydia Strachman Bacal Eduardo Casaroto Lilian Moreira Pinto Jacyr Pasternak Elivane da Silva Victor Oscar Fernando Pavão dos Santos Michael B. Edmond Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults BioMed Research International |
author_facet |
Thiago Zinsly Sampaio Camargo Alexandre R. Marra Nydia Strachman Bacal Eduardo Casaroto Lilian Moreira Pinto Jacyr Pasternak Elivane da Silva Victor Oscar Fernando Pavão dos Santos Michael B. Edmond |
author_sort |
Thiago Zinsly Sampaio Camargo |
title |
Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults |
title_short |
Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults |
title_full |
Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults |
title_fullStr |
Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults |
title_full_unstemmed |
Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults |
title_sort |
evaluation of two methods for determination of cd64 as a diagnostic marker of infection in critically ill adults |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Objectives. Diagnostic markers of infection have had little innovation over the last few decades. CD64, a marker expressed on the surface of neutrophils, may have utility for this purpose. Methods. This study was conducted in an adult intensive care unit (ICU) in São Paulo, Brazil, with 89 patients. We evaluated CD64 in patients with documented or clinically diagnosed infection (infection group) and controls (patients without any evidence of infection) by two different methodologies: method #1, an in house assay, and method #2, the commercial kit Leuko64 (Trillium Diagnostics). Results. CD64 displayed good discriminating power with a 91.2% sensitivity (95% CI 90.7–91.6%) for detecting infection. The commercial kit (Leuko64) demonstrated higher specificity (87.3%) compared with method #1 as well as better accuracy (88.8%). Conclusions. CD64 seems to be a promising marker of infection in the intensive care setting, with Leuko64 showing a slight advantage. |
url |
http://dx.doi.org/10.1155/2016/6593232 |
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