1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
We report the synthesis and biological assessment of 1,3,4-oxadiazole substituted 24 derivatives as novel, potential antibacterial agents. The structures of the newly synthesized derivatives were established by the combined practice of UV, IR, 1H NMR, 13C NMR, and mass spectrometry. Further these sy...
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doaj-d7cdff9d0e3d4dedb1752c4cdfc0b27a2020-11-24T23:09:47ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/1727911727911,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational StudiesSuman Bala0Sunil Kamboj1Anu Kajal2Vipin Saini3Deo Nanadan Prasad4M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaM. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaM. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaM. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaShivalik College of Pharmacy, Nangal, Punjab 140126, IndiaWe report the synthesis and biological assessment of 1,3,4-oxadiazole substituted 24 derivatives as novel, potential antibacterial agents. The structures of the newly synthesized derivatives were established by the combined practice of UV, IR, 1H NMR, 13C NMR, and mass spectrometry. Further these synthesized derivatives were subjected to antibacterial activity against all the selected microbial strains in comparison with amoxicillin and cefixime. The antibacterial activity of synthesized derivatives was correlated with their physicochemical and structural properties by QSAR analysis using computer assisted multiple regression analysis and four sound predictive models were generated with good R2, R adj 2, and Fischer statistic. The derivatives with potent antibacterial activity were subjected to molecular docking studies to investigate the interactions between the active derivatives and amino acid residues existing in the active site of peptide deformylase to assess their antibacterial potential as peptide deformylase inhibitor.http://dx.doi.org/10.1155/2014/172791 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suman Bala Sunil Kamboj Anu Kajal Vipin Saini Deo Nanadan Prasad |
spellingShingle |
Suman Bala Sunil Kamboj Anu Kajal Vipin Saini Deo Nanadan Prasad 1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies BioMed Research International |
author_facet |
Suman Bala Sunil Kamboj Anu Kajal Vipin Saini Deo Nanadan Prasad |
author_sort |
Suman Bala |
title |
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies |
title_short |
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies |
title_full |
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies |
title_fullStr |
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies |
title_full_unstemmed |
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies |
title_sort |
1,3,4-oxadiazole derivatives: synthesis, characterization, antimicrobial potential, and computational studies |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
We report the synthesis and biological assessment of 1,3,4-oxadiazole substituted 24 derivatives as novel, potential antibacterial agents. The structures of the newly synthesized derivatives were established by the combined practice of UV, IR, 1H NMR, 13C NMR, and mass spectrometry. Further these synthesized derivatives were subjected to antibacterial activity against all the selected microbial strains in comparison with amoxicillin and cefixime. The antibacterial activity of synthesized derivatives was correlated with their physicochemical and structural properties by QSAR analysis using computer assisted multiple regression analysis and four sound predictive models were generated with good R2, R
adj
2, and Fischer statistic. The derivatives with potent antibacterial activity were subjected to molecular docking studies to investigate the interactions between the active derivatives and amino acid residues existing in the active site of peptide deformylase to assess their antibacterial potential as peptide deformylase inhibitor. |
url |
http://dx.doi.org/10.1155/2014/172791 |
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