Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of prolifer...

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Bibliographic Details
Main Authors: Tiffany Scarcelli, Jessica F. Jordão, Meaghan A. O'Reilly, Nicholas Ellens, Kullervo Hynynen, Isabelle Aubert
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Brain Stimulation
Subjects:
Focused ultrasound
Cell proliferation
Neurogenesis
Astrogenesis
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X13004051
Description
Summary:Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.
ISSN:1935-861X

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