Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of prolifer...

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Main Authors:	Tiffany Scarcelli, Jessica F. Jordão, Meaghan A. O'Reilly, Nicholas Ellens, Kullervo Hynynen, Isabelle Aubert
Format:	Article
Language:	English
Published:	Elsevier 2014-03-01
Series:	Brain Stimulation
Subjects:	Focused ultrasound Cell proliferation Neurogenesis Astrogenesis Hippocampus
Online Access:	http://www.sciencedirect.com/science/article/pii/S1935861X13004051

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spelling	doaj-d7d4d5c889924f79b1cc81709fc918472021-03-18T04:37:19ZengElsevierBrain Stimulation1935-861X2014-03-0172304307Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult MiceTiffany Scarcelli0Jessica F. Jordão1Meaghan A. O'Reilly2Nicholas Ellens3Kullervo Hynynen4Isabelle Aubert5Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, CanadaPhysical Sciences, Sunnybrook Research Institute, Toronto, ON, CanadaDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, CanadaDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada; Corresponding author. 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada; Corresponding author. 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5.Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.http://www.sciencedirect.com/science/article/pii/S1935861X13004051Focused ultrasoundCell proliferationNeurogenesisAstrogenesisHippocampus
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tiffany Scarcelli Jessica F. Jordão Meaghan A. O'Reilly Nicholas Ellens Kullervo Hynynen Isabelle Aubert
spellingShingle	Tiffany Scarcelli Jessica F. Jordão Meaghan A. O'Reilly Nicholas Ellens Kullervo Hynynen Isabelle Aubert Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice Brain Stimulation Focused ultrasound Cell proliferation Neurogenesis Astrogenesis Hippocampus
author_facet	Tiffany Scarcelli Jessica F. Jordão Meaghan A. O'Reilly Nicholas Ellens Kullervo Hynynen Isabelle Aubert
author_sort	Tiffany Scarcelli
title	Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice
title_short	Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice
title_full	Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice
title_fullStr	Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice
title_full_unstemmed	Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice
title_sort	stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice
publisher	Elsevier
series	Brain Stimulation
issn	1935-861X
publishDate	2014-03-01
description	Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.
topic	Focused ultrasound Cell proliferation Neurogenesis Astrogenesis Hippocampus
url	http://www.sciencedirect.com/science/article/pii/S1935861X13004051
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Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

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