Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells

Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells

Pheochromocytomas and paragangliomas (PPGLs) with activated pseudohypoxic pathways are associated with an immature catecholamine phenotype and carry a higher risk for metastasis. For improved understanding of the underlying mechanisms we investigated the impact of hypoxia and pseudohypoxia on catech...

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Bibliographic Details
Main Authors: Nicole Bechmann, Isabel Poser, Verena Seifert, Christian Greunke, Martin Ullrich, Nan Qin, Axel Walch, Mirko Peitzsch, Mercedes Robledo, Karel Pacak, Jens Pietzsch, Susan Richter, Graeme Eisenhofer
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
hypoxia
pseudohypoxia
spheroids
HIF
EPAS1
catecholamine
pheochromocytoma and paraganglioma
phosphorylation tyrosine hydroxylase
Online Access:https://www.mdpi.com/2072-6694/11/5/594

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