Negative regulation of miR‐1275 by H3K27me3 is critical for glial induction of glioblastoma cells

Negative regulation of miR‐1275 by H3K27me3 is critical for glial induction of glioblastoma cells

Activation of the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway induces glial differentiation of glioblastoma (GBM) cells, but the mechanism by which microRNA (miRNA) regulate this process remains poorly understood. In this study, by performing miRNA genomics and loss‐ and gain‐...

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Bibliographic Details
Main Authors: Jialuo Mai, Jiayu Gu, Ying Liu, Xincheng Liu, Ke Sai, Zhijie Chen, Wanjun Lu, Xiaozhi Yang, Jingyi Wang, Cui Guo, Shuxin Sun, Fan Xing, Longxiang Sheng, Bingzheng Lu, Zhu Zhu, Hongjiaqi Sun, Dongdong Xue, Yuan Lin, Jing Cai, Yaqian Tan, Chuntao Li, Wei Yin, Lin Cao, Ying Ou‐yang, Pengxin Qiu, Xingwen Su, Guangmei Yan, Jiankai Liang, Wenbo Zhu
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Molecular Oncology
Subjects:
cAMP
differentiation therapy
GBM
H3K27me3
miR‐1275
Online Access:https://doi.org/10.1002/1878-0261.12525

Internet

https://doi.org/10.1002/1878-0261.12525

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