BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype

BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype

Human mesenchymal stem cells (MSCs) have the potential to differentiate into nucleus pulposus (NP)-like cells under specific stimulatory conditions. Thus far, the effects of bone morphogenetic protein 3 (BMP3) and the cocktail effects of BMP3 and transforming growth factor (TGF)-β on MSC proliferati...

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Bibliographic Details
Main Authors: Xiaopeng Zhou, Yiqing Tao, Chengzhen Liang, Yujie Zhang, Hao Li, Qixin Chen
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
differentiation
mesenchymal stem cells
transforming growth factor-β
bone morphogenetic protein-3
nucleus pulposus-like cells
Online Access:http://www.mdpi.com/1422-0067/16/9/20344

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