Inhibition of Small Conductance Calcium-Activated Potassium (SK) Channels Prevents Arrhythmias in Rat Atria During β-Adrenergic and Muscarinic Receptor Activation

Inhibition of Small Conductance Calcium-Activated Potassium (SK) Channels Prevents Arrhythmias in Rat Atria During β-Adrenergic and Muscarinic Receptor Activation

Sympathetic and vagal activation is linked to atrial arrhythmogenesis. Here we investigated the small conductance Ca2+-activated K+ (SK)-channel pore-blocker N-(pyridin-2-yl)-4-(pyridine-2-yl)thiazol-2-amine (ICA) on action potential (AP) and atrial fibrillation (AF) parameters in isolated rat atria...

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Bibliographic Details
Main Authors: Lasse Skibsbye, Anne K. Bengaard, A. M. Uldum-Nielsen, Kim Boddum, Torsten Christ, Thomas Jespersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
atrial fibrillation
SK channels
parasympathetic and sympathetic activation
β-adrenergic and muscarinic activation
action potential recordings
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00510/full

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