miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
Oxaliplatin resistance in colorectal cancers is a major clinical problem, and predictive markers are urgently needed. Here, the authors show that miR-625-3pexpression reduces the sensitivity of colorectal cancer cells to oxaliplatin by targeting the kinase MAP2K6, an activator of the MAPK14 pathway.
Bibliographic Details
| Main Authors: |
Mads Heilskov Rasmussen,
Iben Lyskjær,
Rosa Rakownikow Jersie-Christensen,
Line Schmidt Tarpgaard,
Bjarke Primdal-Bengtson,
Morten Muhlig Nielsen,
Jakob Skou Pedersen,
Tine Plato Hansen,
Flemming Hansen,
Jesper Velgaard Olsen,
Per Pfeiffer,
Torben Falck Ørntoft,
Claus Lindbjerg Andersen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12436
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