Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce by or be associated with ITP. Objectives: This study aimed to evaluate complement and humoral immune systems i...
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Mazandaran University of Medical Sciences
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doaj-d7e8e9f38bbd4d1298ecc874b4d2d15a2020-11-25T02:52:40ZengMazandaran University of Medical SciencesJournal of Pediatrics Review2322-43982322-44012020-04-0182133138Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic PurpuraHossein Karami0Javad Ghaffari1Siavash Moradi2Laleh Vahedi3Fatemeh Mohammadi-Kharkeshi4 Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Community Medicine Specialist, Education Development Center, Mazandaran University of Medical Sciences, Sari, Iran. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Pediatrician, Mazandaran University of Medical Sciences, Sari, Iran. Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce by or be associated with ITP. Objectives: This study aimed to evaluate complement and humoral immune systems in ITP. Methods: We evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital and compared them with 30 healthy volunteers. We assessed the samples’ CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry, antistreptolysin O titer by agglutination, CH50, C3, C4 by nephelometry, CD19 by flow cytometry, and anti-tetanus antibody titer by ELISA. Their demographic data were obtained with a questionnaire. Results: Our findings showed that humoral and complement components were normal in both patients and healthy groups. However, based on independent t test results, the mean serum levels of IgM, IgE, IgG1, C3, and tetanus antibody levels were significantly higher in the patient group. Conclusions: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.http://jpr.mazums.ac.ir/article-1-236-en.htmlimmune thrombocytopeniahumeral immunitycomplements systemchildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hossein Karami Javad Ghaffari Siavash Moradi Laleh Vahedi Fatemeh Mohammadi-Kharkeshi |
spellingShingle |
Hossein Karami Javad Ghaffari Siavash Moradi Laleh Vahedi Fatemeh Mohammadi-Kharkeshi Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura Journal of Pediatrics Review immune thrombocytopenia humeral immunity complements system children |
author_facet |
Hossein Karami Javad Ghaffari Siavash Moradi Laleh Vahedi Fatemeh Mohammadi-Kharkeshi |
author_sort |
Hossein Karami |
title |
Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura |
title_short |
Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura |
title_full |
Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura |
title_fullStr |
Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura |
title_full_unstemmed |
Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura |
title_sort |
humoral and complement systems in children with acute immune thrombocytopenic purpura |
publisher |
Mazandaran University of Medical Sciences |
series |
Journal of Pediatrics Review |
issn |
2322-4398 2322-4401 |
publishDate |
2020-04-01 |
description |
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce by or be associated with ITP.
Objectives: This study aimed to evaluate complement and humoral immune systems in ITP.
Methods: We evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital and compared them with 30 healthy volunteers. We assessed the samples’ CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry, antistreptolysin O titer by agglutination, CH50, C3, C4 by nephelometry, CD19 by flow cytometry, and anti-tetanus antibody titer by ELISA. Their demographic data were obtained with a questionnaire.
Results: Our findings showed that humoral and complement components were normal in both patients and healthy groups. However, based on independent t test results, the mean serum levels of IgM, IgE, IgG1, C3, and tetanus antibody levels were significantly higher in the patient group.
Conclusions: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed. |
topic |
immune thrombocytopenia humeral immunity complements system children |
url |
http://jpr.mazums.ac.ir/article-1-236-en.html |
work_keys_str_mv |
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