Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis
Background/Aims: Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD). We performed a quantitative synthesis of the evidence to clarify these...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
Series: | The Saudi Journal of Gastroenterology |
Subjects: | |
Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=4;spage=201;epage=210;aulast=He |
id |
doaj-d7ef37dc248a423a9879669be86de6cc |
---|---|
record_format |
Article |
spelling |
doaj-d7ef37dc248a423a9879669be86de6cc2020-11-25T00:01:20ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492018-01-0124420121010.4103/sjg.SJG_5_18Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysisLiwen HeJiamin ChenJiachen SunJunsheng PengQing HeBackground/Aims: Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD). We performed a quantitative synthesis of the evidence to clarify these associations of TNFSF15 polymorphisms with IBD. Materials and Methods: Data were extracted from PubMed and EMBASE, up to March 15, 2018. Meta-analysis was performed by critically reviewing five studies for rs3810936 polymorphism (2251 cases and 2442 controls), four studies for rs7848647 polymorphism (1503 cases and 1816 controls), and four studies for rs6478108 polymorphism (1502 cases and 1817 controls). Results: Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC). For rs7848647 polymorphism, significantly protective association between this polymorphism and CD risk was also observed, but not in UC. For rs6478108 polymorphism, we also detected a significantly protective association with CD risk in all genetic model but not in UC. Conclusions: This meta-analysis suggests that TNFSF15 polymorphisms may contribute to genetic susceptibility of IBD.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=4;spage=201;epage=210;aulast=HeInflammatory bowel diseasesmeta-analysispolymorphismTNFSF15 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liwen He Jiamin Chen Jiachen Sun Junsheng Peng Qing He |
spellingShingle |
Liwen He Jiamin Chen Jiachen Sun Junsheng Peng Qing He Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis The Saudi Journal of Gastroenterology Inflammatory bowel diseases meta-analysis polymorphism TNFSF15 |
author_facet |
Liwen He Jiamin Chen Jiachen Sun Junsheng Peng Qing He |
author_sort |
Liwen He |
title |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis |
title_short |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis |
title_full |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis |
title_fullStr |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis |
title_full_unstemmed |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis |
title_sort |
protective association of tnfsf15 polymorphisms with crohn's disease and ulcerative colitis: a meta-analysis |
publisher |
Wolters Kluwer Medknow Publications |
series |
The Saudi Journal of Gastroenterology |
issn |
1319-3767 1998-4049 |
publishDate |
2018-01-01 |
description |
Background/Aims: Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD). We performed a quantitative synthesis of the evidence to clarify these associations of TNFSF15 polymorphisms with IBD.
Materials and Methods: Data were extracted from PubMed and EMBASE, up to March 15, 2018. Meta-analysis was performed by critically reviewing five studies for rs3810936 polymorphism (2251 cases and 2442 controls), four studies for rs7848647 polymorphism (1503 cases and 1816 controls), and four studies for rs6478108 polymorphism (1502 cases and 1817 controls).
Results: Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC). For rs7848647 polymorphism, significantly protective association between this polymorphism and CD risk was also observed, but not in UC. For rs6478108 polymorphism, we also detected a significantly protective association with CD risk in all genetic model but not in UC.
Conclusions: This meta-analysis suggests that TNFSF15 polymorphisms may contribute to genetic susceptibility of IBD. |
topic |
Inflammatory bowel diseases meta-analysis polymorphism TNFSF15 |
url |
http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=4;spage=201;epage=210;aulast=He |
work_keys_str_mv |
AT liwenhe protectiveassociationoftnfsf15polymorphismswithcrohnsdiseaseandulcerativecolitisametaanalysis AT jiaminchen protectiveassociationoftnfsf15polymorphismswithcrohnsdiseaseandulcerativecolitisametaanalysis AT jiachensun protectiveassociationoftnfsf15polymorphismswithcrohnsdiseaseandulcerativecolitisametaanalysis AT junshengpeng protectiveassociationoftnfsf15polymorphismswithcrohnsdiseaseandulcerativecolitisametaanalysis AT qinghe protectiveassociationoftnfsf15polymorphismswithcrohnsdiseaseandulcerativecolitisametaanalysis |
_version_ |
1725442590496522240 |