Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this r...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-05-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-02546-x |
id |
doaj-d7f9135a3f5341078c8efaf7cc64e954 |
---|---|
record_format |
Article |
spelling |
doaj-d7f9135a3f5341078c8efaf7cc64e9542020-12-08T03:10:14ZengNature Publishing GroupScientific Reports2045-23222017-05-017111210.1038/s41598-017-02546-xColonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trialEmanuel E. Canfora0Christina M. van der Beek1Johan W. E. Jocken2Gijs H. Goossens3Jens J. Holst4Steven W. M. Olde Damink5Kaatje Lenaerts6Cornelis H. C. Dejong7Ellen E. Blaak8Department of Human Biology, NUTRIM ‘School of Nutrition and Translational Research in Metabolism’, Maastricht University Medical CentreTop Institute Food and NutritionDepartment of Human Biology, NUTRIM ‘School of Nutrition and Translational Research in Metabolism’, Maastricht University Medical CentreDepartment of Human Biology, NUTRIM ‘School of Nutrition and Translational Research in Metabolism’, Maastricht University Medical CentreNNF Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of CopenhagenDepartment of Surgery, NUTRIM ‘School of Nutrition and Translational Research in Metabolism’, Maastricht University Medical CentreTop Institute Food and NutritionTop Institute Food and NutritionDepartment of Human Biology, NUTRIM ‘School of Nutrition and Translational Research in Metabolism’, Maastricht University Medical CentreAbstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.https://doi.org/10.1038/s41598-017-02546-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emanuel E. Canfora Christina M. van der Beek Johan W. E. Jocken Gijs H. Goossens Jens J. Holst Steven W. M. Olde Damink Kaatje Lenaerts Cornelis H. C. Dejong Ellen E. Blaak |
spellingShingle |
Emanuel E. Canfora Christina M. van der Beek Johan W. E. Jocken Gijs H. Goossens Jens J. Holst Steven W. M. Olde Damink Kaatje Lenaerts Cornelis H. C. Dejong Ellen E. Blaak Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial Scientific Reports |
author_facet |
Emanuel E. Canfora Christina M. van der Beek Johan W. E. Jocken Gijs H. Goossens Jens J. Holst Steven W. M. Olde Damink Kaatje Lenaerts Cornelis H. C. Dejong Ellen E. Blaak |
author_sort |
Emanuel E. Canfora |
title |
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial |
title_short |
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial |
title_full |
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial |
title_fullStr |
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial |
title_full_unstemmed |
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial |
title_sort |
colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-05-01 |
description |
Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state. |
url |
https://doi.org/10.1038/s41598-017-02546-x |
work_keys_str_mv |
AT emanuelecanfora colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT christinamvanderbeek colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT johanwejocken colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT gijshgoossens colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT jensjholst colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT stevenwmoldedamink colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT kaatjelenaerts colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT cornelishcdejong colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT elleneblaak colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial |
_version_ |
1724392880303243264 |