The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update
<i>Pneumocystis</i> is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts as obligate intra-pulmonary pathogens. In humans, <i>Pneumocystis j...
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doaj-d809e75cb9164c47820f3b3f7d2f10c92020-11-24T20:46:16ZengMDPI AGPathogens2076-08172019-04-01825210.3390/pathogens8020052pathogens8020052The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An UpdatePatricia Otieno-Odhiambo0Sean Wasserman1J. Claire Hoving2AFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South AfricaWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South AfricaAFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa<i>Pneumocystis</i> is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts as obligate intra-pulmonary pathogens. In humans, <i>Pneumocystis jirovecii</i> is the causative organism of Pneumocystis pneumonia (PCP) in immunocompromised individuals, a serious illness frequently leading to life-threatening respiratory failure. Initially observed in acquired immunodeficiency syndrome (AIDS) patients, PCP is increasingly observed in immunocompromised non-AIDS patients. The evolving epidemiology and persistently poor outcomes of this common infection will require new strategies for diagnosis and treatment. A deeper understanding of host immune responses and of the cells that mediate them will improve the chance of developing new treatment strategies. This brief review provides an update on recent studies on the role of host immunity against <i>Pneumocystis</i>.https://www.mdpi.com/2076-0817/8/2/52<i>Pneumocystis</i><i>Pneumocystis</i> life formsalveolar macrophagesdendritic cellslymphocytes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patricia Otieno-Odhiambo Sean Wasserman J. Claire Hoving |
spellingShingle |
Patricia Otieno-Odhiambo Sean Wasserman J. Claire Hoving The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update Pathogens <i>Pneumocystis</i> <i>Pneumocystis</i> life forms alveolar macrophages dendritic cells lymphocytes |
author_facet |
Patricia Otieno-Odhiambo Sean Wasserman J. Claire Hoving |
author_sort |
Patricia Otieno-Odhiambo |
title |
The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update |
title_short |
The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update |
title_full |
The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update |
title_fullStr |
The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update |
title_full_unstemmed |
The Contribution of Host Cells to <i>Pneumocystis</i> Immunity: An Update |
title_sort |
contribution of host cells to <i>pneumocystis</i> immunity: an update |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2019-04-01 |
description |
<i>Pneumocystis</i> is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts as obligate intra-pulmonary pathogens. In humans, <i>Pneumocystis jirovecii</i> is the causative organism of Pneumocystis pneumonia (PCP) in immunocompromised individuals, a serious illness frequently leading to life-threatening respiratory failure. Initially observed in acquired immunodeficiency syndrome (AIDS) patients, PCP is increasingly observed in immunocompromised non-AIDS patients. The evolving epidemiology and persistently poor outcomes of this common infection will require new strategies for diagnosis and treatment. A deeper understanding of host immune responses and of the cells that mediate them will improve the chance of developing new treatment strategies. This brief review provides an update on recent studies on the role of host immunity against <i>Pneumocystis</i>. |
topic |
<i>Pneumocystis</i> <i>Pneumocystis</i> life forms alveolar macrophages dendritic cells lymphocytes |
url |
https://www.mdpi.com/2076-0817/8/2/52 |
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