Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment

Sputum of cystic fibrosis (CF) patients is a nutrient-rich environment. Higher amino acid content of CF sputum compared to normal sputum plays a major role in the CF-specific phenotype of P. aeruginosa. Presence of amino acids in the sputum-like environment influenced P. aeruginosa quorum-sensing ac...

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Main Author:	Dinesh Diraviam Sriramulu
Format:	Article
Language:	English
Published:	SAGE Publishing 2010-04-01
Series:	Microbiology Insights
Online Access:	http://la-press.com/amino-acids-enhance-adaptive-behaviour-of-pseudomonas-aeruginosa-in-th-a1982

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spelling	doaj-d80a190a5e684f9a8fe5f7e1a828e5562020-11-25T02:34:09ZengSAGE PublishingMicrobiology Insights1178-63612010-04-01201031726Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung EnvironmentDinesh Diraviam SriramuluSputum of cystic fibrosis (CF) patients is a nutrient-rich environment. Higher amino acid content of CF sputum compared to normal sputum plays a major role in the CF-specific phenotype of P. aeruginosa. Presence of amino acids in the sputum-like environment influenced P. aeruginosa quorum-sensing activity and the formation of an unknown exopolysaccharide in the biofilm. Lipopolysaccharides isolated from P. aeruginosa grown in the presence of amino acids enhanced the release of cytokine IL-8 by human kidney and lung epithelial cells. The results of this study provide additional evidence on the role of amino acids towards adaptation of P. aeruginosa to the CF lung environment. http://la-press.com/amino-acids-enhance-adaptive-behaviour-of-pseudomonas-aeruginosa-in-th-a1982
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dinesh Diraviam Sriramulu
spellingShingle	Dinesh Diraviam Sriramulu Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment Microbiology Insights
author_facet	Dinesh Diraviam Sriramulu
author_sort	Dinesh Diraviam Sriramulu
title	Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment
title_short	Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment
title_full	Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment
title_fullStr	Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment
title_full_unstemmed	Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment
title_sort	amino acids enhance adaptive behaviour of pseudomonas aeruginosa in the cystic fibrosis lung environment
publisher	SAGE Publishing
series	Microbiology Insights
issn	1178-6361
publishDate	2010-04-01
description	Sputum of cystic fibrosis (CF) patients is a nutrient-rich environment. Higher amino acid content of CF sputum compared to normal sputum plays a major role in the CF-specific phenotype of P. aeruginosa. Presence of amino acids in the sputum-like environment influenced P. aeruginosa quorum-sensing activity and the formation of an unknown exopolysaccharide in the biofilm. Lipopolysaccharides isolated from P. aeruginosa grown in the presence of amino acids enhanced the release of cytokine IL-8 by human kidney and lung epithelial cells. The results of this study provide additional evidence on the role of amino acids towards adaptation of P. aeruginosa to the CF lung environment.
url	http://la-press.com/amino-acids-enhance-adaptive-behaviour-of-pseudomonas-aeruginosa-in-th-a1982
work_keys_str_mv	AT dineshdiraviamsriramulu aminoacidsenhanceadaptivebehaviourofpseudomonasaeruginosainthecysticfibrosislungenvironment
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Amino Acids Enhance Adaptive Behaviour of Pseudomonas Aeruginosa in the Cystic Fibrosis Lung Environment

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