A Case of Docetaxel Induced Myositis and Review of the Literature
In phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, and fluid retention. With further use of these agents, studies in the late 1980s and early 1990s began to report peripheral neuropathy and proximal muscle weakness as common c...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | Case Reports in Rheumatology |
Online Access: | http://dx.doi.org/10.1155/2015/795242 |
id |
doaj-d821bc70825341748f640c6b6f90d001 |
---|---|
record_format |
Article |
spelling |
doaj-d821bc70825341748f640c6b6f90d0012020-11-24T22:32:08ZengHindawi LimitedCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/795242795242A Case of Docetaxel Induced Myositis and Review of the LiteratureAlexandra Perel-Winkler0Regina Belokovskaya1Isabelle Amigues2Melissa Larusso3Nazia Hussain4Department of Medicine, St. Luke’s-Roosevelt Hospital Center, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10025, USADepartment of Medicine, St. Luke’s-Roosevelt Hospital Center, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10025, USADepartment of Medicine, St. Luke’s-Roosevelt Hospital Center, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10025, USADivision of Rheumatology, Department of Medicine, St. Luke’s-Roosevelt Hospital Center, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10025, USADivision of Rheumatology, Department of Medicine, St. Luke’s-Roosevelt Hospital Center, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10025, USAIn phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, and fluid retention. With further use of these agents, studies in the late 1980s and early 1990s began to report peripheral neuropathy and proximal muscle weakness as common complaints, the later with unexplained pathophysiology. We report a 65-year-old Hispanic woman with estrogen receptor (ER) and progesterone receptor (PR) positive invasive ductal breast carcinoma who presented with right thigh pain and swelling eight days after her third infusion of docetaxel (a taxane chemotherapeutic) and cyclophosphamide. Laboratory findings were notable for elevation in creatine phosphokinase (CPK), aldolase, and erythrocyte sedimentation rate (ESR); a magnetic resonance imaging (MRI) of her lower extremities showed evidence of bilateral muscle edema involving the anterior compartment muscles of the thighs. A workup to rule out other causes of myositis was negative. Docetaxel was not reintroduced and the patient improved with corticosteroids. Since 2005 this is, to our knowledge, the fifth reported case of docetaxel related inflammatory myositis. Taxanes have been noted to cause disabling but transient arthralgias and myalgias; it is important to consider the possibility of inflammatory myopathy as a possible complication in patients undergoing treatment with these agents.http://dx.doi.org/10.1155/2015/795242 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandra Perel-Winkler Regina Belokovskaya Isabelle Amigues Melissa Larusso Nazia Hussain |
spellingShingle |
Alexandra Perel-Winkler Regina Belokovskaya Isabelle Amigues Melissa Larusso Nazia Hussain A Case of Docetaxel Induced Myositis and Review of the Literature Case Reports in Rheumatology |
author_facet |
Alexandra Perel-Winkler Regina Belokovskaya Isabelle Amigues Melissa Larusso Nazia Hussain |
author_sort |
Alexandra Perel-Winkler |
title |
A Case of Docetaxel Induced Myositis and Review of the Literature |
title_short |
A Case of Docetaxel Induced Myositis and Review of the Literature |
title_full |
A Case of Docetaxel Induced Myositis and Review of the Literature |
title_fullStr |
A Case of Docetaxel Induced Myositis and Review of the Literature |
title_full_unstemmed |
A Case of Docetaxel Induced Myositis and Review of the Literature |
title_sort |
case of docetaxel induced myositis and review of the literature |
publisher |
Hindawi Limited |
series |
Case Reports in Rheumatology |
issn |
2090-6889 2090-6897 |
publishDate |
2015-01-01 |
description |
In phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, and fluid retention. With further use of these agents, studies in the late 1980s and early 1990s began to report peripheral neuropathy and proximal muscle weakness as common complaints, the later with unexplained pathophysiology. We report a 65-year-old Hispanic woman with estrogen receptor (ER) and progesterone receptor (PR) positive invasive ductal breast carcinoma who presented with right thigh pain and swelling eight days after her third infusion of docetaxel (a taxane chemotherapeutic) and cyclophosphamide. Laboratory findings were notable for elevation in creatine phosphokinase (CPK), aldolase, and erythrocyte sedimentation rate (ESR); a magnetic resonance imaging (MRI) of her lower extremities showed evidence of bilateral muscle edema involving the anterior compartment muscles of the thighs. A workup to rule out other causes of myositis was negative. Docetaxel was not reintroduced and the patient improved with corticosteroids. Since 2005 this is, to our knowledge, the fifth reported case of docetaxel related inflammatory myositis. Taxanes have been noted to cause disabling but transient arthralgias and myalgias; it is important to consider the possibility of inflammatory myopathy as a possible complication in patients undergoing treatment with these agents. |
url |
http://dx.doi.org/10.1155/2015/795242 |
work_keys_str_mv |
AT alexandraperelwinkler acaseofdocetaxelinducedmyositisandreviewoftheliterature AT reginabelokovskaya acaseofdocetaxelinducedmyositisandreviewoftheliterature AT isabelleamigues acaseofdocetaxelinducedmyositisandreviewoftheliterature AT melissalarusso acaseofdocetaxelinducedmyositisandreviewoftheliterature AT naziahussain acaseofdocetaxelinducedmyositisandreviewoftheliterature AT alexandraperelwinkler caseofdocetaxelinducedmyositisandreviewoftheliterature AT reginabelokovskaya caseofdocetaxelinducedmyositisandreviewoftheliterature AT isabelleamigues caseofdocetaxelinducedmyositisandreviewoftheliterature AT melissalarusso caseofdocetaxelinducedmyositisandreviewoftheliterature AT naziahussain caseofdocetaxelinducedmyositisandreviewoftheliterature |
_version_ |
1725734821494259712 |