DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

Neuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by DOT1L activity, which regulates H3K79me2 accumula...

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Main Authors:	Francesco Ferrari, Laura Arrigoni, Henriette Franz, Annalisa Izzo, Ludmila Butenko, Eirini Trompouki, Tanja Vogel, Thomas Manke
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19001-7

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spelling	doaj-d822e6cfeb8648068ea652e7f3ceda8d2021-05-11T09:09:25ZengNature Publishing GroupNature Communications2041-17232020-10-0111111310.1038/s41467-020-19001-7DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibilityFrancesco Ferrari0Laura Arrigoni1Henriette Franz2Annalisa Izzo3Ludmila Butenko4Eirini Trompouki5Tanja Vogel6Thomas Manke7Max Planck Institute of Immunobiology and EpigeneticsMax Planck Institute of Immunobiology and EpigeneticsInstitute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgInstitute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgInstitute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgMax Planck Institute of Immunobiology and EpigeneticsInstitute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgMax Planck Institute of Immunobiology and EpigeneticsNeuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by DOT1L activity, which regulates H3K79me2 accumulation, and preserves accessibility of SOX2-bound enhancers.https://doi.org/10.1038/s41467-020-19001-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Francesco Ferrari Laura Arrigoni Henriette Franz Annalisa Izzo Ludmila Butenko Eirini Trompouki Tanja Vogel Thomas Manke
spellingShingle	Francesco Ferrari Laura Arrigoni Henriette Franz Annalisa Izzo Ludmila Butenko Eirini Trompouki Tanja Vogel Thomas Manke DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility Nature Communications
author_facet	Francesco Ferrari Laura Arrigoni Henriette Franz Annalisa Izzo Ludmila Butenko Eirini Trompouki Tanja Vogel Thomas Manke
author_sort	Francesco Ferrari
title	DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility
title_short	DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility
title_full	DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility
title_fullStr	DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility
title_full_unstemmed	DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility
title_sort	dot1l-mediated murine neuronal differentiation associates with h3k79me2 accumulation and preserves sox2-enhancer accessibility
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Neuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by DOT1L activity, which regulates H3K79me2 accumulation, and preserves accessibility of SOX2-bound enhancers.
url	https://doi.org/10.1038/s41467-020-19001-7
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DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

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