GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under certain circumstances α cells can express the prohormone convertase required for proglucagon processing to GLP-1, prohormone conv...
Main Authors: | Mridusmita Saikia, Marlena M. Holter, Leanne R. Donahue, Isaac S. Lee, Qiaonan C. Zheng, Journey L. Wise, Jenna E. Todero, Daryl J. Phuong, Darline Garibay, Reilly Coch, Kyle W. Sloop, Adolfo Garcia-Ocana, Charles G. Danko, Bethany P. Cummings |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Clinical investigation
2021-02-01
|
Series: | JCI Insight |
Subjects: | |
Online Access: | https://doi.org/10.1172/jci.insight.141851 |
Similar Items
-
Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R–dependent manner
by: Sara L. Jepsen, et al.
Published: (2021-02-01) -
GLP-1 REGULATES PROLIFERATION OF GLP-1 SECRETING CELLS THROUGH A FEEDBACK MECHANISM
by: Abdullahi Mohamed, Mohamed
Published: (2010) -
β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice
by: Darline Garibay, et al.
Published: (2018-04-01) -
Endocrinologie et communications cellulaires
by: Idelman, Simon
Published: (2001) -
Vasily Shervinsky ? Russian doctor, scientist, therapeutist and pathologist, Honored Scientist of the RSFSR AND THE FOUNDER OF THE RUSSIAN ENDOCRINOLOGY SCHOOL
by: N D Ivanova
Published: (2013-06-01)