In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations
The evaluation of UV-filter in vitro percutaneous absorption allows the estimation of the systemic exposure dose (SED) and the margin of safety (MoS) of sunscreen products. As both the vehicle and pattern of application may affect sunscreen safety and efficacy, we evaluated in vitro release and skin...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-02-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4923/10/1/27 |
id |
doaj-d827a56aed16424ea3a762d7311cc190 |
---|---|
record_format |
Article |
spelling |
doaj-d827a56aed16424ea3a762d7311cc1902020-11-25T00:46:41ZengMDPI AGPharmaceutics1999-49232018-02-011012710.3390/pharmaceutics10010027pharmaceutics10010027In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical FormulationsLucia Montenegro0Rita Turnaturi1Carmela Parenti2Lorella Pasquinucci3Department of Drug Sciences, Pharmaceutical Technology Section, University of Catania, Viale A. Doria 6, 95125 Catania, ItalyRita Turnaturi Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, ItalyCarmela Parenti Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A. Doria 6, 95125 Catania, ItalyLorella Pasquinucci Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, ItalyThe evaluation of UV-filter in vitro percutaneous absorption allows the estimation of the systemic exposure dose (SED) and the margin of safety (MoS) of sunscreen products. As both the vehicle and pattern of application may affect sunscreen safety and efficacy, we evaluated in vitro release and skin permeation of two widely used UV-filters, octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane (BMBM) from topical formulations with different features (oil in water (O/W) emulsions with different viscosity, water in oil (W/O) emulsion, oils with different lipophilicity). To mimic in-use conditions, we carried out experiments repeating sunscreen application on the skin surface for three consecutive days. BMBM release from all these vehicles was very low, thus leading to poor skin permeation. The vehicle composition significantly affected OMC release and skin permeation, and slight increases of OMC permeation were observed after repeated applications. From skin permeation data, SED and MoS values of BMBM and OMC were calculated for all the investigated formulations after a single application and repeated applications. While MoS values of BMBM were always well beyond the accepted safety limit, the safety of sunscreen formulations containing OMC may depend on the vehicle composition and the application pattern.http://www.mdpi.com/1999-4923/10/1/27sunscreentopical formulationsafetyskin permeationoctyl methoxycinnamatebutylmethoxydibenzoylmethanerepeated application |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucia Montenegro Rita Turnaturi Carmela Parenti Lorella Pasquinucci |
spellingShingle |
Lucia Montenegro Rita Turnaturi Carmela Parenti Lorella Pasquinucci In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations Pharmaceutics sunscreen topical formulation safety skin permeation octyl methoxycinnamate butylmethoxydibenzoylmethane repeated application |
author_facet |
Lucia Montenegro Rita Turnaturi Carmela Parenti Lorella Pasquinucci |
author_sort |
Lucia Montenegro |
title |
In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations |
title_short |
In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations |
title_full |
In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations |
title_fullStr |
In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations |
title_full_unstemmed |
In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations |
title_sort |
in vitro evaluation of sunscreen safety: effects of the vehicle and repeated applications on skin permeation from topical formulations |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2018-02-01 |
description |
The evaluation of UV-filter in vitro percutaneous absorption allows the estimation of the systemic exposure dose (SED) and the margin of safety (MoS) of sunscreen products. As both the vehicle and pattern of application may affect sunscreen safety and efficacy, we evaluated in vitro release and skin permeation of two widely used UV-filters, octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane (BMBM) from topical formulations with different features (oil in water (O/W) emulsions with different viscosity, water in oil (W/O) emulsion, oils with different lipophilicity). To mimic in-use conditions, we carried out experiments repeating sunscreen application on the skin surface for three consecutive days. BMBM release from all these vehicles was very low, thus leading to poor skin permeation. The vehicle composition significantly affected OMC release and skin permeation, and slight increases of OMC permeation were observed after repeated applications. From skin permeation data, SED and MoS values of BMBM and OMC were calculated for all the investigated formulations after a single application and repeated applications. While MoS values of BMBM were always well beyond the accepted safety limit, the safety of sunscreen formulations containing OMC may depend on the vehicle composition and the application pattern. |
topic |
sunscreen topical formulation safety skin permeation octyl methoxycinnamate butylmethoxydibenzoylmethane repeated application |
url |
http://www.mdpi.com/1999-4923/10/1/27 |
work_keys_str_mv |
AT luciamontenegro invitroevaluationofsunscreensafetyeffectsofthevehicleandrepeatedapplicationsonskinpermeationfromtopicalformulations AT ritaturnaturi invitroevaluationofsunscreensafetyeffectsofthevehicleandrepeatedapplicationsonskinpermeationfromtopicalformulations AT carmelaparenti invitroevaluationofsunscreensafetyeffectsofthevehicleandrepeatedapplicationsonskinpermeationfromtopicalformulations AT lorellapasquinucci invitroevaluationofsunscreensafetyeffectsofthevehicleandrepeatedapplicationsonskinpermeationfromtopicalformulations |
_version_ |
1725263734539026432 |