Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging

Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging

The development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photop...

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Main Authors: Zhihao Guo, Xiuji Wang, Pei Wei, Yihua Gao, Qin Li
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Analytical Methods in Chemistry
Online Access:http://dx.doi.org/10.1155/2019/8130767
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spelling doaj-d82a29e99e854c9eaaef5d606cf9c0ef2020-11-25T02:41:39ZengHindawi LimitedJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/81307678130767Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell ImagingZhihao Guo0Xiuji Wang1Pei Wei2Yihua Gao3Qin Li4Analysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaThe development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photophysical studies show that L1 exhibits excellent sensitivity and selectivity towards Cu2+ to other metal ions in neutral acetonitrile aqueous media. Mechanism studies suggest that the recognition process may associate with a Cu2+ promoted hydrolysis reaction of L1. Furthermore, L1 has been successfully applied in fluorescence imaging of Cu2+ ion in living cells.http://dx.doi.org/10.1155/2019/8130767
collection DOAJ
language English
format Article
sources DOAJ
author Zhihao Guo
Xiuji Wang
Pei Wei
Yihua Gao
Qin Li
spellingShingle Zhihao Guo
Xiuji Wang
Pei Wei
Yihua Gao
Qin Li
Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
Journal of Analytical Methods in Chemistry
author_facet Zhihao Guo
Xiuji Wang
Pei Wei
Yihua Gao
Qin Li
author_sort Zhihao Guo
title Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
title_short Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
title_full Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
title_fullStr Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
title_full_unstemmed Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
title_sort highly selective fluorescent probe for the detection of copper (ii) and its application in live cell imaging
publisher Hindawi Limited
series Journal of Analytical Methods in Chemistry
issn 2090-8865
2090-8873
publishDate 2019-01-01
description The development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photophysical studies show that L1 exhibits excellent sensitivity and selectivity towards Cu2+ to other metal ions in neutral acetonitrile aqueous media. Mechanism studies suggest that the recognition process may associate with a Cu2+ promoted hydrolysis reaction of L1. Furthermore, L1 has been successfully applied in fluorescence imaging of Cu2+ ion in living cells.
url http://dx.doi.org/10.1155/2019/8130767
work_keys_str_mv AT zhihaoguo highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging
AT xiujiwang highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging
AT peiwei highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging
AT yihuagao highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging
AT qinli highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging
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