The dynamics of adult neurogenesis in human hippocampus

• Main Authors: Amadi O Ihunwo, Lackson H Tembo, Charles Dzamalala
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016-01-01
• Series: Neural Regeneration Research
• Subjects: adult neurogenesis; neuron; neuronal stem cell; proliferation; differentiation; neuronal turn-over; hippocampus; human neurogenesis
• Online Access: http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=12;spage=1869;epage=1883;aulast=Ihunwo

The phenomenon of adult neurogenesis is now an accepted occurrence in mammals and also in humans. At least two discrete places house stem cells for generation of neurons in adult brain. These are olfactory system and the hippocampus. In animals, newly generated neurons have been directly or indirectly demonstrated to generate a significant amount of new neurons to have a functional role. However, the data in humans on the extent of this process is still scanty and such as difficult to comprehend its functional role in humans. This paper explores the available data on as extent of adult hippocampal neurogenesis in humans and makes comparison to animal data.