Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions
Relative to healthy controls, anxiety-disorder patients show anomalies in classical conditioning that may either result from, or provide a risk factor for, clinically relevant anxiety. Here, we investigated whether healthy participants with enhanced anxiety vulnerability show abnormalities in a chal...
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doaj-d8316a8bc187411ba3e3f99e168525c82020-11-24T20:58:59ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532015-06-01910.3389/fnbeh.2015.00155132187Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditionsMaimu Alissa Rehbein0Maimu Alissa Rehbein1Ida eWessing2Pienie eZwitserlood3Pienie eZwitserlood4Christian eSteinberg5Christian eSteinberg6Annuschka Salima Eden7Annuschka Salima Eden8Christian eDobel9Christian eDobel10Markus eJunghoefer11Markus eJunghoefer12University Hospital MünsterUniversity of MünsterUniversity Hospital MünsterUniversity of MünsterUniversity of MünsterUniversity Hospital MünsterUniversity of MünsterUniversity Hospital MünsterUniversity of MünsterUniversity Hospital MünsterUniversity of MünsterUniversity Hospital MünsterUniversity of MünsterRelative to healthy controls, anxiety-disorder patients show anomalies in classical conditioning that may either result from, or provide a risk factor for, clinically relevant anxiety. Here, we investigated whether healthy participants with enhanced anxiety vulnerability show abnormalities in a challenging affective-conditioning paradigm, in which many stimulus-reinforcer associations had to be acquired with only few learning trials. Forty-seven high and low trait-anxious females underwent MultiCS conditioning, in which 52 different neutral faces (CS+) were paired with an aversive noise (US), while further 52 faces (CS-) remained unpaired. Emotional learning was assessed by evaluative (rating), behavioral (dot-probe, contingency report), and neurophysiological (magnetoencephalography) measures before, during, and after learning. High and low trait-anxious groups did not differ in evaluative ratings or response priming before or after conditioning. High trait-anxious women, however, were better than low trait-anxious women at reporting CS+/US contingencies after conditioning, and showed an enhanced prefrontal cortex activation towards CS+ in the M1 (i.e., 80 to 117 ms) and M170 time intervals (i.e., 140 to 160 ms) during acquisition. These effects in MultiCS conditioning observed in individuals with elevated trait anxiety are consistent with theories of enhanced conditionability in anxiety vulnerability. Furthermore, they point towards increased threat monitoring and detection in highly trait-anxious females, possibly mediated by alterations in visual working memory.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00155/fullMagnetoencephalographyEEGMEGworking memoryClassical Conditioningtrait anxiety |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Maimu Alissa Rehbein Maimu Alissa Rehbein Ida eWessing Pienie eZwitserlood Pienie eZwitserlood Christian eSteinberg Christian eSteinberg Annuschka Salima Eden Annuschka Salima Eden Christian eDobel Christian eDobel Markus eJunghoefer Markus eJunghoefer |
spellingShingle |
Maimu Alissa Rehbein Maimu Alissa Rehbein Ida eWessing Pienie eZwitserlood Pienie eZwitserlood Christian eSteinberg Christian eSteinberg Annuschka Salima Eden Annuschka Salima Eden Christian eDobel Christian eDobel Markus eJunghoefer Markus eJunghoefer Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions Frontiers in Behavioral Neuroscience Magnetoencephalography EEG MEG working memory Classical Conditioning trait anxiety |
author_facet |
Maimu Alissa Rehbein Maimu Alissa Rehbein Ida eWessing Pienie eZwitserlood Pienie eZwitserlood Christian eSteinberg Christian eSteinberg Annuschka Salima Eden Annuschka Salima Eden Christian eDobel Christian eDobel Markus eJunghoefer Markus eJunghoefer |
author_sort |
Maimu Alissa Rehbein |
title |
Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions |
title_short |
Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions |
title_full |
Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions |
title_fullStr |
Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions |
title_full_unstemmed |
Rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions |
title_sort |
rapid prefrontal cortex activation towards aversively paired faces and enhanced contingency detection are observed in highly trait-anxious women under challenging conditions |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2015-06-01 |
description |
Relative to healthy controls, anxiety-disorder patients show anomalies in classical conditioning that may either result from, or provide a risk factor for, clinically relevant anxiety. Here, we investigated whether healthy participants with enhanced anxiety vulnerability show abnormalities in a challenging affective-conditioning paradigm, in which many stimulus-reinforcer associations had to be acquired with only few learning trials. Forty-seven high and low trait-anxious females underwent MultiCS conditioning, in which 52 different neutral faces (CS+) were paired with an aversive noise (US), while further 52 faces (CS-) remained unpaired. Emotional learning was assessed by evaluative (rating), behavioral (dot-probe, contingency report), and neurophysiological (magnetoencephalography) measures before, during, and after learning. High and low trait-anxious groups did not differ in evaluative ratings or response priming before or after conditioning. High trait-anxious women, however, were better than low trait-anxious women at reporting CS+/US contingencies after conditioning, and showed an enhanced prefrontal cortex activation towards CS+ in the M1 (i.e., 80 to 117 ms) and M170 time intervals (i.e., 140 to 160 ms) during acquisition. These effects in MultiCS conditioning observed in individuals with elevated trait anxiety are consistent with theories of enhanced conditionability in anxiety vulnerability. Furthermore, they point towards increased threat monitoring and detection in highly trait-anxious females, possibly mediated by alterations in visual working memory. |
topic |
Magnetoencephalography EEG MEG working memory Classical Conditioning trait anxiety |
url |
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00155/full |
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