A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α.
TRIM5α is a key cross-species barrier to retroviral infection, with certain TRIM5 alleles conferring increased risk of HIV-1 infection in humans. TRIM5α is best known as a species-specific restriction factor that directly inhibits the viral life cycle. Additionally, it is also a pattern-recognition...
Main Authors: | Bhaskar Saha, Devon Chisholm, Alison M Kell, Michael A Mandell |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-10-01
|
Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1009017 |
Similar Items
-
Characterisation of TRIM5α and related retroviral restriction factors
by: Schaller, T.
Published: (2009) -
TRIM5α selectively binds a restriction-sensitive retroviral capsid
by: Luban Jeremy, et al.
Published: (2005-06-01) -
Characterising retroviral restriction by TRIM proteins
by: Fraser, S. J.
Published: (2016) -
Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α
by: Jonathan M Wagner, et al.
Published: (2016-06-01) -
TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition.
by: Marcin D Roganowicz, et al.
Published: (2017-10-01)