Acidic Preconditioning Inhibits Na+/H+ and Na+/Ca2+ Exchanger Interaction via PKCε in Guinea-Pig Ventricular Myocytes

Acidic Preconditioning Inhibits Na+/H+ and Na+/Ca2+ Exchanger Interaction via PKCε in Guinea-Pig Ventricular Myocytes

An interaction between the Na+/Ca2+ exchanger (NCX) and the Na+/H+ exchanger (NHE) induces reperfusion injury. We investigated the effect of brief repetitive acidosis as acidic preconditioning on NCX and NHE interaction during recovery from acidosis. NCX current with the reversal potential was measu...

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Bibliographic Details
Main Authors: Libing Li, Yasuhide Watanabe, Isao Matsuoka, Junko Kimura
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319314185

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