DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules

Novel DNA materials promise unpredictable perspectives for applications in cell biology. The realization of DNA-hydrogels built by a controlled association of DNA nanostars, whose binding can be tuned with minor changes in the nucleotide sequences, has been recently described. DNA hydrogels, with sp...

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Main Authors:	Enrico Lattuada, Manuela Leo, Debora Caprara, Luisa Salvatori, Antonella Stoppacciaro, Francesco Sciortino, Patrizia Filetici
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Series:	Frontiers in Pharmacology
Subjects:	nanomaterials DNA-GEL gelation biomedical applications delivery of bioactive molecules
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.01345/full

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record_format	Article
spelling	doaj-d839384eb5824c35af1f4842eb6af2dd2020-11-25T04:04:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-09-011110.3389/fphar.2020.01345564013DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive MoleculesEnrico Lattuada0Manuela Leo1Debora Caprara2Luisa Salvatori3Antonella Stoppacciaro4Francesco Sciortino5Patrizia Filetici6Department of Physics, Sapienza University of Rome, Rome, ItalyDepartment of Physics, Sapienza University of Rome, Rome, ItalyDepartment of Physics, Sapienza University of Rome, Rome, ItalyInstitute of Molecular Biology and Pathology - CNR, Sapienza University of Rome, Rome, ItalyDepartment of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Physics, Sapienza University of Rome, Rome, ItalyInstitute of Molecular Biology and Pathology - CNR, Sapienza University of Rome, Rome, ItalyNovel DNA materials promise unpredictable perspectives for applications in cell biology. The realization of DNA-hydrogels built by a controlled association of DNA nanostars, whose binding can be tuned with minor changes in the nucleotide sequences, has been recently described. DNA hydrogels, with specific gelation properties that can be reassambled in desired culture media supplemented with drugs, RNA, DNA molecules and other bioactive compounds offer the opportunity to develop a novel nanomaterial for the delivery of single or multiple drugs in tumor tissues as an innovative and promising strategy. We provide here a comprehensive description of different, recently realized DNA-gels with the perspective of stimulating their biomedical application. Finally, we discuss the possibility to design sophisticated 3D tissue-like DNA-gels incorporating cell spheroids or single cells for the assembly of a novel kind of cellular matrix as a preclinical investigation for the implementation of tools for in vivo delivery of bioactive molecules.https://www.frontiersin.org/article/10.3389/fphar.2020.01345/fullnanomaterialsDNA-GELgelationbiomedical applicationsdelivery of bioactive molecules
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Enrico Lattuada Manuela Leo Debora Caprara Luisa Salvatori Antonella Stoppacciaro Francesco Sciortino Patrizia Filetici
spellingShingle	Enrico Lattuada Manuela Leo Debora Caprara Luisa Salvatori Antonella Stoppacciaro Francesco Sciortino Patrizia Filetici DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules Frontiers in Pharmacology nanomaterials DNA-GEL gelation biomedical applications delivery of bioactive molecules
author_facet	Enrico Lattuada Manuela Leo Debora Caprara Luisa Salvatori Antonella Stoppacciaro Francesco Sciortino Patrizia Filetici
author_sort	Enrico Lattuada
title	DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules
title_short	DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules
title_full	DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules
title_fullStr	DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules
title_full_unstemmed	DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules
title_sort	dna-gel, novel nanomaterial for biomedical applications and delivery of bioactive molecules
publisher	Frontiers Media S.A.
series	Frontiers in Pharmacology
issn	1663-9812
publishDate	2020-09-01
description	Novel DNA materials promise unpredictable perspectives for applications in cell biology. The realization of DNA-hydrogels built by a controlled association of DNA nanostars, whose binding can be tuned with minor changes in the nucleotide sequences, has been recently described. DNA hydrogels, with specific gelation properties that can be reassambled in desired culture media supplemented with drugs, RNA, DNA molecules and other bioactive compounds offer the opportunity to develop a novel nanomaterial for the delivery of single or multiple drugs in tumor tissues as an innovative and promising strategy. We provide here a comprehensive description of different, recently realized DNA-gels with the perspective of stimulating their biomedical application. Finally, we discuss the possibility to design sophisticated 3D tissue-like DNA-gels incorporating cell spheroids or single cells for the assembly of a novel kind of cellular matrix as a preclinical investigation for the implementation of tools for in vivo delivery of bioactive molecules.
topic	nanomaterials DNA-GEL gelation biomedical applications delivery of bioactive molecules
url	https://www.frontiersin.org/article/10.3389/fphar.2020.01345/full
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DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules

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