Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory.
Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Ser...
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doaj-d8479eb6b6874416b63f4b6de278e1372020-11-25T01:49:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011212e018892710.1371/journal.pone.0188927Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory.Daniel P BlissMark D'EspositoRecent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown. In the present study, we investigate the circuit-level origins of serial dependence in a biophysical model of cortex. We explore two distinct kinds of mechanisms: stable persistent activity during the memory delay period and dynamic "activity-silent" synaptic plasticity. We find that networks endowed with both strong reverberation to support persistent activity and dynamic synapses can closely reproduce behavioral serial dependence. Specifically, elevated activity drives synaptic augmentation, which biases activity on the subsequent trial, giving rise to a spatiotemporally tuned shift in the population response. Our hybrid neural model is a theoretical advance beyond abstract mathematical characterizations, offers testable hypotheses for physiological research, and demonstrates the power of biological insights to provide a quantitative explanation of human behavior.http://europepmc.org/articles/PMC5731753?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel P Bliss Mark D'Esposito |
spellingShingle |
Daniel P Bliss Mark D'Esposito Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. PLoS ONE |
author_facet |
Daniel P Bliss Mark D'Esposito |
author_sort |
Daniel P Bliss |
title |
Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. |
title_short |
Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. |
title_full |
Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. |
title_fullStr |
Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. |
title_full_unstemmed |
Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. |
title_sort |
synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown. In the present study, we investigate the circuit-level origins of serial dependence in a biophysical model of cortex. We explore two distinct kinds of mechanisms: stable persistent activity during the memory delay period and dynamic "activity-silent" synaptic plasticity. We find that networks endowed with both strong reverberation to support persistent activity and dynamic synapses can closely reproduce behavioral serial dependence. Specifically, elevated activity drives synaptic augmentation, which biases activity on the subsequent trial, giving rise to a spatiotemporally tuned shift in the population response. Our hybrid neural model is a theoretical advance beyond abstract mathematical characterizations, offers testable hypotheses for physiological research, and demonstrates the power of biological insights to provide a quantitative explanation of human behavior. |
url |
http://europepmc.org/articles/PMC5731753?pdf=render |
work_keys_str_mv |
AT danielpbliss synapticaugmentationinacorticalcircuitmodelreproducesserialdependenceinvisualworkingmemory AT markdesposito synapticaugmentationinacorticalcircuitmodelreproducesserialdependenceinvisualworkingmemory |
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1725004238979858432 |