Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review
Introduction: Attention deficit hyperactivity disorder (ADHD) is generally treated with pharmacological interventions such as psychostimulants. The most used widely used one is methylphenidate followed by atomoxetine. Purpose: To identify, synthesize and evaluate the best available evidence on the e...
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Online Access: | http://dx.doi.org/10.5867/medwave.2012.08.5471 |
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doaj-d8569fa529614a6aa4c57e57a377524a2020-11-24T22:24:03ZengMedwave Estudios LimitadaMedwave0717-63842012-09-011208e5471Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic reviewJosé CallejaJosé UribarrIntroduction: Attention deficit hyperactivity disorder (ADHD) is generally treated with pharmacological interventions such as psychostimulants. The most used widely used one is methylphenidate followed by atomoxetine. Purpose: To identify, synthesize and evaluate the best available evidence on the effectiveness and safety of atomoxetine in ADHD treatment in the 6-19 year-old population. Methods: A systematic review of intervention studies that evaluated effectiveness of atomoxetine compared with placebo and methylphenidate was conducted. Outcomes assessed were educational functioning, psychosocial functioning, quality of life and adverse effects. The search was done up to February 2012 in English and Spanish in the following databases: PubMed/MEDLINE, LILACS, Cochrane, DARE and National Guideline Clearinghouse. The articles were independently evaluated by two investigators. Results: Of the 108 studies found initially, 11 were included, among which five systematic reviews, one primary article and 5 clinical guidelines. Conclusions: Atomoxetine is recommended as a second option in ADHD and was found to be superior to placebo. Its use is recommended when methylphenidate fails or comorbidities are present. http://dx.doi.org/10.5867/medwave.2012.08.5471attention deficit disorder with hyperactivityatomoxetinesystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Calleja José Uribarr |
spellingShingle |
José Calleja José Uribarr Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review Medwave attention deficit disorder with hyperactivity atomoxetine systematic review |
author_facet |
José Calleja José Uribarr |
author_sort |
José Calleja |
title |
Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review |
title_short |
Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review |
title_full |
Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review |
title_fullStr |
Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review |
title_full_unstemmed |
Effectiveness and safety of atomoxetine for ADHD in population between 6 and 19 years: a systematic review |
title_sort |
effectiveness and safety of atomoxetine for adhd in population between 6 and 19 years: a systematic review |
publisher |
Medwave Estudios Limitada |
series |
Medwave |
issn |
0717-6384 |
publishDate |
2012-09-01 |
description |
Introduction: Attention deficit hyperactivity disorder (ADHD) is generally treated with pharmacological interventions such as psychostimulants. The most used widely used one is methylphenidate followed by atomoxetine. Purpose: To identify, synthesize and evaluate the best available evidence on the effectiveness and safety of atomoxetine in ADHD treatment in the 6-19 year-old population. Methods: A systematic review of intervention studies that evaluated effectiveness of atomoxetine compared with placebo and methylphenidate was conducted. Outcomes assessed were educational functioning, psychosocial functioning, quality of life and adverse effects. The search was done up to February 2012 in English and Spanish in the following databases: PubMed/MEDLINE, LILACS, Cochrane, DARE and National Guideline Clearinghouse. The articles were independently evaluated by two investigators. Results: Of the 108 studies found initially, 11 were included, among which five systematic reviews, one primary article and 5 clinical guidelines. Conclusions: Atomoxetine is recommended as a second option in ADHD and was found to be superior to placebo. Its use is recommended when methylphenidate fails or comorbidities are present. |
topic |
attention deficit disorder with hyperactivity atomoxetine systematic review |
url |
http://dx.doi.org/10.5867/medwave.2012.08.5471 |
work_keys_str_mv |
AT josecalleja effectivenessandsafetyofatomoxetineforadhdinpopulationbetween6and19yearsasystematicreview AT joseuribarr effectivenessandsafetyofatomoxetineforadhdinpopulationbetween6and19yearsasystematicreview |
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