Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage
Objectives: Perivascular adipose tissue plays a key role in atherosclerosis, but its effects on the composition of carotid atherosclerotic plaques are unknown. This study aimed to investigate the association between inflammatory carotid artery and intraplaque hemorrhage (IPH) in the carotid artery.M...
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2021-09-01
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doaj-d85ea9ad02a84649957b097a64fa28552021-09-20T04:48:17ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-09-01810.3389/fcvm.2021.735794735794Association Between Carotid Artery Perivascular Fat Density and Intraplaque HemorrhageShuai Zhang0Hui Gu1Xinxin Yu2Bing Kang3Xianshun Yuan4Ximing Wang5School of Medicine, Shandong First Medical University, Jinan, ChinaShandong Provincial Hospital Affliated to Shandong First Medical University, Jinan, ChinaShandong Provincial Hospital Affliated to Shandong First Medical University, Jinan, ChinaShandong Provincial Hospital Affliated to Shandong First Medical University, Jinan, ChinaShandong Provincial Hospital Affliated to Shandong First Medical University, Jinan, ChinaShandong Provincial Hospital Affliated to Shandong First Medical University, Jinan, ChinaObjectives: Perivascular adipose tissue plays a key role in atherosclerosis, but its effects on the composition of carotid atherosclerotic plaques are unknown. This study aimed to investigate the association between inflammatory carotid artery and intraplaque hemorrhage (IPH) in the carotid artery.Methods: This is a single-center retrospective study. Carotid inflammation was assessed by perivascular fat density (PFD) in 72 participants (mean age, 65.1 years; 56 men) who underwent both computed tomography angiography (CTA) and magnetic resonance imaging (MRI) within 2 weeks. The presence of IPH was assessed with MRI. Carotid stenosis, maximum plaque thickness, calcification, and ulceration were evaluated through CTA. The association between PFD and the occurrence of IPH was studied using generalized estimating equations analysis.Results: Of 156 plaques, 72 plaques (46.2%) had IPH. Plaques with IPH showed higher PFD than those without [−41.4 ± 3.9 vs. −55.8 ± 6.5 Hounsfield unit (HU); p < 0.001]. After age, calcification, degree of stenosis, maximum plaque thickness, and ulceration were adjusted for, PFD (OR, 1.96; 95% CI, 1.41–2.73; p < 0.001) was found to be strongly associated with the presence of IPH.Conclusions: A higher PFD is associated with the presence of IPH in the carotid artery. These findings may provide a novel marker to identify carotid IPH and risk stratification.https://www.frontiersin.org/articles/10.3389/fcvm.2021.735794/fullatherosclerosiscarotid arteryintraplaque hemorrhageperivascular fatinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuai Zhang Hui Gu Xinxin Yu Bing Kang Xianshun Yuan Ximing Wang |
spellingShingle |
Shuai Zhang Hui Gu Xinxin Yu Bing Kang Xianshun Yuan Ximing Wang Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage Frontiers in Cardiovascular Medicine atherosclerosis carotid artery intraplaque hemorrhage perivascular fat inflammation |
author_facet |
Shuai Zhang Hui Gu Xinxin Yu Bing Kang Xianshun Yuan Ximing Wang |
author_sort |
Shuai Zhang |
title |
Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage |
title_short |
Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage |
title_full |
Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage |
title_fullStr |
Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage |
title_full_unstemmed |
Association Between Carotid Artery Perivascular Fat Density and Intraplaque Hemorrhage |
title_sort |
association between carotid artery perivascular fat density and intraplaque hemorrhage |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-09-01 |
description |
Objectives: Perivascular adipose tissue plays a key role in atherosclerosis, but its effects on the composition of carotid atherosclerotic plaques are unknown. This study aimed to investigate the association between inflammatory carotid artery and intraplaque hemorrhage (IPH) in the carotid artery.Methods: This is a single-center retrospective study. Carotid inflammation was assessed by perivascular fat density (PFD) in 72 participants (mean age, 65.1 years; 56 men) who underwent both computed tomography angiography (CTA) and magnetic resonance imaging (MRI) within 2 weeks. The presence of IPH was assessed with MRI. Carotid stenosis, maximum plaque thickness, calcification, and ulceration were evaluated through CTA. The association between PFD and the occurrence of IPH was studied using generalized estimating equations analysis.Results: Of 156 plaques, 72 plaques (46.2%) had IPH. Plaques with IPH showed higher PFD than those without [−41.4 ± 3.9 vs. −55.8 ± 6.5 Hounsfield unit (HU); p < 0.001]. After age, calcification, degree of stenosis, maximum plaque thickness, and ulceration were adjusted for, PFD (OR, 1.96; 95% CI, 1.41–2.73; p < 0.001) was found to be strongly associated with the presence of IPH.Conclusions: A higher PFD is associated with the presence of IPH in the carotid artery. These findings may provide a novel marker to identify carotid IPH and risk stratification. |
topic |
atherosclerosis carotid artery intraplaque hemorrhage perivascular fat inflammation |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.735794/full |
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