Nestin+ cells direct inflammatory cell migration in atherosclerosis

Nestin+ cells direct inflammatory cell migration in atherosclerosis

Bone marrow cells producing the intermediate filament nestin guide monocyte egress to the bloodstream in response to infection. Here, the authors show that nestin-producing stromal cells direct inflammatory cell migration in atherosclerosis, and that stromal Mcp1 is crucial in this process.

Bibliographic Details
Main Authors: Raquel del Toro, Raphael Chèvre, Cristina Rodríguez, Antonio Ordóñez, José Martínez-González, Vicente Andrés, Simón Méndez-Ferrer
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12706
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spelling doaj-d85f91f8f35e4acba42bea0a4d9319562021-05-11T10:58:13ZengNature Publishing GroupNature Communications2041-17232016-09-017111210.1038/ncomms12706Nestin+ cells direct inflammatory cell migration in atherosclerosisRaquel del Toro0Raphael Chèvre1Cristina Rodríguez2Antonio Ordóñez3José Martínez-González4Vicente Andrés5Simón Méndez-Ferrer6Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro de Investigación Cardiovascular (CSIC-ICCC), IIB-Sant PauGrupo de Fisiopatología Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS)Centro de Investigación Cardiovascular (CSIC-ICCC), IIB-Sant PauCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Bone marrow cells producing the intermediate filament nestin guide monocyte egress to the bloodstream in response to infection. Here, the authors show that nestin-producing stromal cells direct inflammatory cell migration in atherosclerosis, and that stromal Mcp1 is crucial in this process.https://doi.org/10.1038/ncomms12706
collection DOAJ
language English
format Article
sources DOAJ
author Raquel del Toro
Raphael Chèvre
Cristina Rodríguez
Antonio Ordóñez
José Martínez-González
Vicente Andrés
Simón Méndez-Ferrer
spellingShingle Raquel del Toro
Raphael Chèvre
Cristina Rodríguez
Antonio Ordóñez
José Martínez-González
Vicente Andrés
Simón Méndez-Ferrer
Nestin+ cells direct inflammatory cell migration in atherosclerosis
Nature Communications
author_facet Raquel del Toro
Raphael Chèvre
Cristina Rodríguez
Antonio Ordóñez
José Martínez-González
Vicente Andrés
Simón Méndez-Ferrer
author_sort Raquel del Toro
title Nestin+ cells direct inflammatory cell migration in atherosclerosis
title_short Nestin+ cells direct inflammatory cell migration in atherosclerosis
title_full Nestin+ cells direct inflammatory cell migration in atherosclerosis
title_fullStr Nestin+ cells direct inflammatory cell migration in atherosclerosis
title_full_unstemmed Nestin+ cells direct inflammatory cell migration in atherosclerosis
title_sort nestin+ cells direct inflammatory cell migration in atherosclerosis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description Bone marrow cells producing the intermediate filament nestin guide monocyte egress to the bloodstream in response to infection. Here, the authors show that nestin-producing stromal cells direct inflammatory cell migration in atherosclerosis, and that stromal Mcp1 is crucial in this process.
url https://doi.org/10.1038/ncomms12706
work_keys_str_mv AT raqueldeltoro nestincellsdirectinflammatorycellmigrationinatherosclerosis
AT raphaelchevre nestincellsdirectinflammatorycellmigrationinatherosclerosis
AT cristinarodriguez nestincellsdirectinflammatorycellmigrationinatherosclerosis
AT antonioordonez nestincellsdirectinflammatorycellmigrationinatherosclerosis
AT josemartinezgonzalez nestincellsdirectinflammatorycellmigrationinatherosclerosis
AT vicenteandres nestincellsdirectinflammatorycellmigrationinatherosclerosis
AT simonmendezferrer nestincellsdirectinflammatorycellmigrationinatherosclerosis
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