Tablet Formulation Containing Chitosan-Alginate Microparticles: Characterization and Release Profile of Xanthones
Mangosteen pericarp extract contains a high amount of xanthones, which are secondary plant metabolites that exhibit high antioxidant activities as well as beneficial pharmacological properties, but low bioavailabilities. In this study, xanthones extracted from the pericarp of soursop fruit were...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2020-11-01
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| Series: | International Journal of Technology |
| Subjects: | |
| Online Access: | https://ijtech.eng.ui.ac.id/article/view/4338 |
| Summary: | Mangosteen pericarp extract contains a high amount of
xanthones, which are secondary plant metabolites that exhibit high antioxidant
activities as well as beneficial pharmacological properties, but low
bioavailabilities. In this study, xanthones extracted from the
pericarp of soursop fruit were encapsulated in chitosan-alginate microparticles
by ionic gelation, and the
microparticles were subsequently formulated into
antioxidant supplement tablets by direct compression. One of
the tablet formulations satisfied the requirements for weight and size
uniformity as well as friability, but not hardness. Dissolution test results
revealed similar release profiles characterized by a burst release that occurs
in the first 60 min of immersion in simulated gastrointestinal fluids and a
complete release of xanthones in 120 min. The results obtained herein
demonstrated the potential of the tested tablet formulations for the delivery
of xanthones into the gastrointestinal tract. If a targeted release to a
specific area in the gastrointestinal tract is desirable, the composition of
the excipients in the present formulation should be modified. |
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| ISSN: | 2086-9614 2087-2100 |