Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus)
The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and no...
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doaj-d878d26f71cb464298420b0eaa8869442020-11-24T21:30:08ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/243825243825Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus)Rovena Clara G. J. Engelberth0Kayo Diogenes de A. Silva1Carolina V. de M. Azevedo2Elaine Cristina Gavioli3Jose Ronaldo dos Santos4Joacil Germano Soares5Expedito S. Nascimento Junior6Judney C. Cavalcante7Miriam Stela M. O. Costa8Jeferson S. Cavalcante9Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilLaboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilLaboratory of Chronobiology, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilBehavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, BrazilBiology Department, Federal University of Sergipe, Aracaju, SE, BrazilLaboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilLaboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilLaboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilLaboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilLaboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, BrazilThe suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging.http://dx.doi.org/10.1155/2014/243825 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rovena Clara G. J. Engelberth Kayo Diogenes de A. Silva Carolina V. de M. Azevedo Elaine Cristina Gavioli Jose Ronaldo dos Santos Joacil Germano Soares Expedito S. Nascimento Junior Judney C. Cavalcante Miriam Stela M. O. Costa Jeferson S. Cavalcante |
spellingShingle |
Rovena Clara G. J. Engelberth Kayo Diogenes de A. Silva Carolina V. de M. Azevedo Elaine Cristina Gavioli Jose Ronaldo dos Santos Joacil Germano Soares Expedito S. Nascimento Junior Judney C. Cavalcante Miriam Stela M. O. Costa Jeferson S. Cavalcante Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) BioMed Research International |
author_facet |
Rovena Clara G. J. Engelberth Kayo Diogenes de A. Silva Carolina V. de M. Azevedo Elaine Cristina Gavioli Jose Ronaldo dos Santos Joacil Germano Soares Expedito S. Nascimento Junior Judney C. Cavalcante Miriam Stela M. O. Costa Jeferson S. Cavalcante |
author_sort |
Rovena Clara G. J. Engelberth |
title |
Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) |
title_short |
Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) |
title_full |
Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) |
title_fullStr |
Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) |
title_full_unstemmed |
Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) |
title_sort |
morphological changes in the suprachiasmatic nucleus of aging female marmosets (callithrix jacchus) |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging. |
url |
http://dx.doi.org/10.1155/2014/243825 |
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