MULTIPLE CEREBRAL MELANOMA METASTASES WITH UNKNOWN PRIMARY TUMOR LOCATION: A CASE REPORT

• Main Authors: Liviu Cozma, Delia Tulba, Maria Barsevschi, Cristina Mitu, Laura Dumitrescu, Radu Tanasescu, Bogdan Ovidiu Popescu
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2017-12-01
• Series: Romanian Journal of Neurology
• Subjects: cerebral metastases; unknown primary tumor; melanoma; braf mutation; swi hypointensity; fluid-blood level
• Online Access: https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2017-Nr.4/RJN_2017_4_Art-09.pdf

Introduction. Diagnostic and therapeutic approach of multiple cerebral lesions is often challenging. Case report. A 66-year-old man with unremarkable medical history was admitted to our hospital for recent inability and stereotyped movements of the left upper limb. Brain MRI identifi ed eight tumoral masses with contrast enhancement and marked SWI signal loss that displayed increased metabolic activity on 18F-FDG PET/CT scan. Cerebral biopsy led to the diagnosis of melanoma with BRAF V600E mutation. Stereotactic radiosurgery and molecular therapy were planned afterwards. Conclusion. Brain MRI is an useful tool in guiding diagnosis of cerebral metastases of unknown origin.