Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Ganglioneuromas (GN) are rare, mature tumors that arise in the posterior mediastinum or retroperitoneum from neural crest cells and present as slow growing masses in the pediatric population. While they are often found incidentally in unrelated diagnostic workup, they can become symptomatic due to t...

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Main Authors: Cameron L. Brock, MS, Apoorva Sharma, MS, Fabio A. Villada, MD, Johanna Schubert, MD
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Radiology Case Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043320305288
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spelling doaj-d88f7baf9e604f83bd49467a3d63fc412020-12-01T04:05:04ZengElsevierRadiology Case Reports1930-04332021-01-011611821Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imagingCameron L. Brock, MS0Apoorva Sharma, MS1Fabio A. Villada, MD2Johanna Schubert, MD3Department of Radiology, CHI Creighton University Medical Center-Bergan Mercy, 7500 Mercy Rd, Omaha, NE 68124; Corresponding author (C. L. Brock)Department of Pathology, CHI Creighton University Medical Center-Bergan Mercy, 7500 Mercy Rd, Omaha, NE 68124Department of Radiology, CHI Creighton University Medical Center-Bergan Mercy, 7500 Mercy Rd, Omaha, NE 68124Department of Radiology, CHI Creighton University Medical Center-Bergan Mercy, 7500 Mercy Rd, Omaha, NE 68124Ganglioneuromas (GN) are rare, mature tumors that arise in the posterior mediastinum or retroperitoneum from neural crest cells and present as slow growing masses in the pediatric population. While they are often found incidentally in unrelated diagnostic workup, they can become symptomatic due to their size and location. They typically demonstrate the nonspecific appearance of a solid mass without invasive or destructive features across different modalities. Such features are normally indicative of more aggressive neoplasms from similar cellular ancestry or an entirely different lineage. Here we present a case of mediastinal GN that on imaging was initially suggestive of an osteochondroma with malignant degeneration based on the presence of an exostosis associated with a large solid mass. Final pathology, however, revealed GN with involvement of the adjacent bone. While the final diagnosis was benign, it is important to recognize this pattern of exostosis with solid mass, especially since the overall survival rate of sarcomata is much worse than that of a classic GN.http://www.sciencedirect.com/science/article/pii/S1930043320305288GanglioneuromaMediastinal massOsteochondromaBone invasion
collection DOAJ
language English
format Article
sources DOAJ
author Cameron L. Brock, MS
Apoorva Sharma, MS
Fabio A. Villada, MD
Johanna Schubert, MD
spellingShingle Cameron L. Brock, MS
Apoorva Sharma, MS
Fabio A. Villada, MD
Johanna Schubert, MD
Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging
Radiology Case Reports
Ganglioneuroma
Mediastinal mass
Osteochondroma
Bone invasion
author_facet Cameron L. Brock, MS
Apoorva Sharma, MS
Fabio A. Villada, MD
Johanna Schubert, MD
author_sort Cameron L. Brock, MS
title Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging
title_short Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging
title_full Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging
title_fullStr Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging
title_full_unstemmed Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging
title_sort mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on ct imaging
publisher Elsevier
series Radiology Case Reports
issn 1930-0433
publishDate 2021-01-01
description Ganglioneuromas (GN) are rare, mature tumors that arise in the posterior mediastinum or retroperitoneum from neural crest cells and present as slow growing masses in the pediatric population. While they are often found incidentally in unrelated diagnostic workup, they can become symptomatic due to their size and location. They typically demonstrate the nonspecific appearance of a solid mass without invasive or destructive features across different modalities. Such features are normally indicative of more aggressive neoplasms from similar cellular ancestry or an entirely different lineage. Here we present a case of mediastinal GN that on imaging was initially suggestive of an osteochondroma with malignant degeneration based on the presence of an exostosis associated with a large solid mass. Final pathology, however, revealed GN with involvement of the adjacent bone. While the final diagnosis was benign, it is important to recognize this pattern of exostosis with solid mass, especially since the overall survival rate of sarcomata is much worse than that of a classic GN.
topic Ganglioneuroma
Mediastinal mass
Osteochondroma
Bone invasion
url http://www.sciencedirect.com/science/article/pii/S1930043320305288
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