Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study
ItalyPurpose: In this study, we aimed to determine the role of extracorporeal shockwave therapy (ESWT) in the management of Peyronie’s disease (PD). Materials and Methods: A total of 325 patients suffering from PD were enrolled in this single-arm clinical study. All patients were received ESWT using...
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Korean Society for Sexual Medicine and Andrology
2019-09-01
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doaj-d89f78527b7e4d7b93004e48dcf9a6702020-11-24T21:54:06ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902019-09-0137333934610.5534/wjmh.180100Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational StudyMarina di Mauro0Giorgio Ivan Russo1Pier Andrea Della Camera2Fabrizio di Maida3Gianmartin Cito4Nicola Mondaini5Marco Capece6Marco Falcone7Francesco Sessa8Andrea Mari9Riccardo Campi10Carlotta Sabini11Sergio Serni12Mauro Gacci13Andrea Minervini14Marco Carini15Sebastiano Cimino16Girolamo Morelli17Andrea Cocci18Urology Section, Department of Surgery, University of Catania, CataniaUrology Section, Department of Surgery, University of Catania, CataniaDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceAndrology Center, Villa Donatello Hospital, Florence,Department of Urology, University of Naples, Naples,Department of Urology, Molinette Hospital, University of Turin, TurinDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceDepartment of Urology, University of FlorenceUrology Section, Department of Surgery, University of Catania, CataniaDepartment of Urology, University of Pisa, Pisa, ItalyDepartment of Urology, University of FlorenceItalyPurpose: In this study, we aimed to determine the role of extracorporeal shockwave therapy (ESWT) in the management of Peyronie’s disease (PD). Materials and Methods: A total of 325 patients suffering from PD were enrolled in this single-arm clinical study. All patients were received ESWT using a schedule of 1 treatment/wk. Penile curvature was measured by a goniometer after intracavernosal drug-induced erection using Alprostadil. Plaque size was measured with a ruler and sexual function assessed by the international index of erectile function (IIEF)-15 score. Severity of erectile dysfunction was classified as severe (IIEF-15 ≤10), moderate (IIEF-15 between 11 and 16), or mild (IIEF-15 between 17 and 25). Results were evaluated at baseline and 3 months after the treatment.Results: All the patients completed the study protocol. Median age was 59.0 years (55.0–64.0 years). After treatment, the median (interquartile range, IQR) plaque size reduced from 1.78 cm2 (1.43–2.17 cm2) to 1.53 cm2 (1.31–1.96 cm2) (p<0.001); the median (IQR) penile length in erection increased from 13.0 cm (12.0–14.0 cm) to 14 cm (13.0–15.0 cm) (p<0.001) and the median (IQR) penile curvature from 30.4° (22.2°–35.4°) to 25.0° (20.2°–30.4°) (p<0.001). We also observed a decrease in pain assessed by visual analogue scale (7 vs. 3; p<0.001), an improvement in each of the IIEF sub-domains (p<0.001) and an improvement in all three PD questionnaire domains (p<0.001). Conclusions: Based on our findings, ESWT could be considered a safe and efficient minimally invasive option for the management of the patients suffering from PD.Erectile dysfunctionExtracorporeal shockwave therapyPenile diseasesPenile indurationPeyronie’s diseaseTreatment |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marina di Mauro Giorgio Ivan Russo Pier Andrea Della Camera Fabrizio di Maida Gianmartin Cito Nicola Mondaini Marco Capece Marco Falcone Francesco Sessa Andrea Mari Riccardo Campi Carlotta Sabini Sergio Serni Mauro Gacci Andrea Minervini Marco Carini Sebastiano Cimino Girolamo Morelli Andrea Cocci |
spellingShingle |
Marina di Mauro Giorgio Ivan Russo Pier Andrea Della Camera Fabrizio di Maida Gianmartin Cito Nicola Mondaini Marco Capece Marco Falcone Francesco Sessa Andrea Mari Riccardo Campi Carlotta Sabini Sergio Serni Mauro Gacci Andrea Minervini Marco Carini Sebastiano Cimino Girolamo Morelli Andrea Cocci Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study The World Journal of Men's Health Erectile dysfunction Extracorporeal shockwave therapy Penile diseases Penile induration Peyronie’s disease Treatment |
author_facet |
Marina di Mauro Giorgio Ivan Russo Pier Andrea Della Camera Fabrizio di Maida Gianmartin Cito Nicola Mondaini Marco Capece Marco Falcone Francesco Sessa Andrea Mari Riccardo Campi Carlotta Sabini Sergio Serni Mauro Gacci Andrea Minervini Marco Carini Sebastiano Cimino Girolamo Morelli Andrea Cocci |
author_sort |
Marina di Mauro |
title |
Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study |
title_short |
Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study |
title_full |
Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study |
title_fullStr |
Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study |
title_full_unstemmed |
Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study |
title_sort |
extracorporeal shock wave therapy in peyronie’s disease: clinical efficacy and safety from a single-arm observational study |
publisher |
Korean Society for Sexual Medicine and Andrology |
series |
The World Journal of Men's Health |
issn |
2287-4208 2287-4690 |
publishDate |
2019-09-01 |
description |
ItalyPurpose: In this study, we aimed to determine the role of extracorporeal shockwave therapy (ESWT) in the management of Peyronie’s disease (PD). Materials and Methods: A total of 325 patients suffering from PD were enrolled in this single-arm clinical study. All patients were received ESWT using a schedule of 1 treatment/wk. Penile curvature was measured by a goniometer after intracavernosal drug-induced erection using Alprostadil. Plaque size was measured with a ruler and sexual function assessed by the international index of erectile function (IIEF)-15 score. Severity of erectile dysfunction was classified as severe (IIEF-15 ≤10), moderate (IIEF-15 between 11 and 16), or mild (IIEF-15 between 17 and 25). Results were evaluated at baseline and 3 months after the treatment.Results: All the patients completed the study protocol. Median age was 59.0 years (55.0–64.0 years). After treatment, the median (interquartile range, IQR) plaque size reduced from 1.78 cm2 (1.43–2.17 cm2) to 1.53 cm2 (1.31–1.96 cm2) (p<0.001); the median (IQR) penile length in erection increased from 13.0 cm (12.0–14.0 cm) to 14 cm (13.0–15.0 cm) (p<0.001) and the median (IQR) penile curvature from 30.4° (22.2°–35.4°) to 25.0° (20.2°–30.4°) (p<0.001). We also observed a decrease in pain assessed by visual analogue scale (7 vs. 3; p<0.001), an improvement in each of the IIEF sub-domains (p<0.001) and an improvement in all three PD questionnaire domains (p<0.001). Conclusions: Based on our findings, ESWT could be considered a safe and efficient minimally invasive option for the management of the patients suffering from PD. |
topic |
Erectile dysfunction Extracorporeal shockwave therapy Penile diseases Penile induration Peyronie’s disease Treatment |
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