The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

Lisa Lindström et al. find that the gamma-tubulin cellular network is required to maintain mitochondrial function and organization in the cell. Knockdown of gamma-tubulin or loss of its GTPase domain disrupts the mitochondrial network and alters respiratory capacity and expression of mitochondrial g...

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Main Authors:	Lisa Lindström, Tongbin Li, Darina Malycheva, Arun Kancharla, Helén Nilsson, Neelanjan Vishnu, Hindrik Mulder, Martin Johansson, Catalina Ana Rosselló, Maria Alvarado-Kristensson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-018-0037-3

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spelling	doaj-d8b682b135e44aecbc719b783aa778cd2020-12-07T23:51:22ZengNature Publishing GroupCommunications Biology2399-36422018-05-011111810.1038/s42003-018-0037-3The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organizationLisa Lindström0Tongbin Li1Darina Malycheva2Arun Kancharla3Helén Nilsson4Neelanjan Vishnu5Hindrik Mulder6Martin Johansson7Catalina Ana Rosselló8Maria Alvarado-Kristensson9Molecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöAccuraScience LLCMolecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöMolecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöPathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöUnit of Molecular Metabolism, Lund University Diabetes Centre MalmöUnit of Molecular Metabolism, Lund University Diabetes Centre MalmöPathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöMolecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöMolecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital MalmöLisa Lindström et al. find that the gamma-tubulin cellular network is required to maintain mitochondrial function and organization in the cell. Knockdown of gamma-tubulin or loss of its GTPase domain disrupts the mitochondrial network and alters respiratory capacity and expression of mitochondrial genes.https://doi.org/10.1038/s42003-018-0037-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lisa Lindström Tongbin Li Darina Malycheva Arun Kancharla Helén Nilsson Neelanjan Vishnu Hindrik Mulder Martin Johansson Catalina Ana Rosselló Maria Alvarado-Kristensson
spellingShingle	Lisa Lindström Tongbin Li Darina Malycheva Arun Kancharla Helén Nilsson Neelanjan Vishnu Hindrik Mulder Martin Johansson Catalina Ana Rosselló Maria Alvarado-Kristensson The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization Communications Biology
author_facet	Lisa Lindström Tongbin Li Darina Malycheva Arun Kancharla Helén Nilsson Neelanjan Vishnu Hindrik Mulder Martin Johansson Catalina Ana Rosselló Maria Alvarado-Kristensson
author_sort	Lisa Lindström
title	The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
title_short	The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
title_full	The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
title_fullStr	The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
title_full_unstemmed	The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
title_sort	gtpase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2018-05-01
description	Lisa Lindström et al. find that the gamma-tubulin cellular network is required to maintain mitochondrial function and organization in the cell. Knockdown of gamma-tubulin or loss of its GTPase domain disrupts the mitochondrial network and alters respiratory capacity and expression of mitochondrial genes.
url	https://doi.org/10.1038/s42003-018-0037-3
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The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

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