The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment

Yue Liu,1 Nina Liu,2 Wenwen Shen,1 Longhui Li,1 Wenhua Zhou,1 Leiting Xu3 1Department of Academic Research, Ningbo Kangning Hospital, Key Laboratory of Addiction Research of Zhejiang Province, Ningbo, 315201, People’s Republic of China; 2Department of Basic Medicine, Ningbo College of Heal...

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Main Authors: Liu Y, Liu N, Shen W, Li L, Zhou W, Xu L
Format: Article
Language:English
Published: Dove Medical Press 2021-05-01
Series:Drug Design, Development and Therapy
Subjects:
Online Access:https://www.dovepress.com/the-abuse-characteristics-of-amphetamine-type-stimulants-in-patients-r-peer-reviewed-fulltext-article-DDDT
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spelling doaj-d8ba6272636e46cdac6f731bc563c45a2021-05-18T21:18:18ZengDove Medical PressDrug Design, Development and Therapy1177-88812021-05-01Volume 152109211664881The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance TreatmentLiu YLiu NShen WLi LZhou WXu LYue Liu,1 Nina Liu,2 Wenwen Shen,1 Longhui Li,1 Wenhua Zhou,1 Leiting Xu3 1Department of Academic Research, Ningbo Kangning Hospital, Key Laboratory of Addiction Research of Zhejiang Province, Ningbo, 315201, People’s Republic of China; 2Department of Basic Medicine, Ningbo College of Health Sciences, Ningbo, 315100, People’s Republic of China; 3Department of Basic Medicine, Ningbo University School of Medicine, Ningbo, 315211, People’s Republic of ChinaCorrespondence: Leiting XuDepartment of Basic Medicine, Ningbo University School of Medicine, Ningbo, 315211, People’s Republic of ChinaTel +86 18267417969Email leitingxu@yeah.netWenhua ZhouDepartment of Academic Research, Ningbo Kangning Hospital, Key Laboratory of Addiction Research of Zhejiang Province, Ningbo, 315201, People’s Republic of ChinaTel +86 13777113984Email wenhuazhou@yeah.netObjective: The purpose of this study was to retrospectively investigate the abuse characteristics of amphetamine-type stimulants (ATS) in patients receiving methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT).Methods: A total of 58 MMT and 51 BMT patients abusing ATS were recruited from the drug maintenance treatment clinic of Ningbo Addiction Research and Treatment Center from January 2018 to December 2019. They were assessed using the amphetamine abuse questionnaire (AAQ), addiction severity index (ASI) and Barratt impulsiveness scale (BIS). Moreover, 40 MMT control patients, 40 BMT control patients and 20 healthy controls were also assessed using the BIS. All information was collected using the amphetamine abuse questionnaire (AAQ), Chinese version of addiction severity index (ASI-C) and Chinese version of Barratt impulsiveness scale (BIS-C) conducted by qualified psychologists.Results: The interval of amphetamine use in the MMT group was shorter than the BMT group (P < 0.05). The drug use subscale score of ASI was higher in the MMT group than the BMT group (P < 0.05). The respective and total scores of attentional impulsiveness, motor impulsiveness and non-planning impulsiveness in BIS in the MMT group were all higher than the MMT control group (P < 0.05). The scores of motor impulsiveness and non-planning impulsiveness in the BMT group were higher than the BMT control group (P < 0.05). The respective and total scores in BIS in the MMT control group and the BMT control group were all higher than those in the healthy controls.Conclusion: The patients showing amphetamine abuse in maintenance therapy had a greater impulsiveness than those having other simple maintenance treatments, and patients under MMT may be more addicted to amphetamines in comparison with those having BMT.Keywords: methadone maintenance treatment, buprenorphine maintenance treatment, amphetamine-type stimulants, impulsiveness, addictionhttps://www.dovepress.com/the-abuse-characteristics-of-amphetamine-type-stimulants-in-patients-r-peer-reviewed-fulltext-article-DDDTmethadone maintenance treatmentbuprenorphine maintenance treatmentamphetamine-type stimulantsimpulsivenessaddiction
collection DOAJ
language English
format Article
sources DOAJ
author Liu Y
Liu N
Shen W
Li L
Zhou W
Xu L
spellingShingle Liu Y
Liu N
Shen W
Li L
Zhou W
Xu L
The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
Drug Design, Development and Therapy
methadone maintenance treatment
buprenorphine maintenance treatment
amphetamine-type stimulants
impulsiveness
addiction
author_facet Liu Y
Liu N
Shen W
Li L
Zhou W
Xu L
author_sort Liu Y
title The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
title_short The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
title_full The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
title_fullStr The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
title_full_unstemmed The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
title_sort abuse characteristics of amphetamine-type stimulants in patients receiving methadone maintenance treatment and buprenorphine maintenance treatment
publisher Dove Medical Press
series Drug Design, Development and Therapy
issn 1177-8881
publishDate 2021-05-01
description Yue Liu,1 Nina Liu,2 Wenwen Shen,1 Longhui Li,1 Wenhua Zhou,1 Leiting Xu3 1Department of Academic Research, Ningbo Kangning Hospital, Key Laboratory of Addiction Research of Zhejiang Province, Ningbo, 315201, People’s Republic of China; 2Department of Basic Medicine, Ningbo College of Health Sciences, Ningbo, 315100, People’s Republic of China; 3Department of Basic Medicine, Ningbo University School of Medicine, Ningbo, 315211, People’s Republic of ChinaCorrespondence: Leiting XuDepartment of Basic Medicine, Ningbo University School of Medicine, Ningbo, 315211, People’s Republic of ChinaTel +86 18267417969Email leitingxu@yeah.netWenhua ZhouDepartment of Academic Research, Ningbo Kangning Hospital, Key Laboratory of Addiction Research of Zhejiang Province, Ningbo, 315201, People’s Republic of ChinaTel +86 13777113984Email wenhuazhou@yeah.netObjective: The purpose of this study was to retrospectively investigate the abuse characteristics of amphetamine-type stimulants (ATS) in patients receiving methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT).Methods: A total of 58 MMT and 51 BMT patients abusing ATS were recruited from the drug maintenance treatment clinic of Ningbo Addiction Research and Treatment Center from January 2018 to December 2019. They were assessed using the amphetamine abuse questionnaire (AAQ), addiction severity index (ASI) and Barratt impulsiveness scale (BIS). Moreover, 40 MMT control patients, 40 BMT control patients and 20 healthy controls were also assessed using the BIS. All information was collected using the amphetamine abuse questionnaire (AAQ), Chinese version of addiction severity index (ASI-C) and Chinese version of Barratt impulsiveness scale (BIS-C) conducted by qualified psychologists.Results: The interval of amphetamine use in the MMT group was shorter than the BMT group (P < 0.05). The drug use subscale score of ASI was higher in the MMT group than the BMT group (P < 0.05). The respective and total scores of attentional impulsiveness, motor impulsiveness and non-planning impulsiveness in BIS in the MMT group were all higher than the MMT control group (P < 0.05). The scores of motor impulsiveness and non-planning impulsiveness in the BMT group were higher than the BMT control group (P < 0.05). The respective and total scores in BIS in the MMT control group and the BMT control group were all higher than those in the healthy controls.Conclusion: The patients showing amphetamine abuse in maintenance therapy had a greater impulsiveness than those having other simple maintenance treatments, and patients under MMT may be more addicted to amphetamines in comparison with those having BMT.Keywords: methadone maintenance treatment, buprenorphine maintenance treatment, amphetamine-type stimulants, impulsiveness, addiction
topic methadone maintenance treatment
buprenorphine maintenance treatment
amphetamine-type stimulants
impulsiveness
addiction
url https://www.dovepress.com/the-abuse-characteristics-of-amphetamine-type-stimulants-in-patients-r-peer-reviewed-fulltext-article-DDDT
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