The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?

The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?

Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited...

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Bibliographic Details
Main Authors: Jeffrey M. Ryckman, Bradley N. Reames, Kelsey A. Klute, William A. Hall, Michael J. Baine, May Abdel-Wahab, Chi Lin
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Pancreatic cancer
Stereotactic body radiotherapy
Total neoadjuvant therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630821000392
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spelling doaj-d8bf5383a44a49a6a63bfaa9e2ca55f62021-06-02T21:20:33ZengElsevierClinical and Translational Radiation Oncology2405-63082021-05-0128124128The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?Jeffrey M. Ryckman0Bradley N. Reames1Kelsey A. Klute2William A. Hall3Michael J. Baine4May Abdel-Wahab5Chi Lin6Department of Radiation Oncology, West Virginia University Cancer Institute, Parkersburg, WV, USA; Corresponding author at: West Virginia University Cancer Institute, Camden Clark Comprehensive Regional Cancer Center, 705 Garfield Avenue, Suite 180, Parkersburg, WV 26101, USA.Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USADepartment of Medical Oncology, University of Nebraska Medical Center, Omaha, NE, USADepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USADepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USADivision of Human Health, International Atomic Energy Agency, Vienna, AustriaDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USAStereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes.http://www.sciencedirect.com/science/article/pii/S2405630821000392Pancreatic cancerStereotactic body radiotherapyTotal neoadjuvant therapy
collection DOAJ
language English
format Article
sources DOAJ
author Jeffrey M. Ryckman
Bradley N. Reames
Kelsey A. Klute
William A. Hall
Michael J. Baine
May Abdel-Wahab
Chi Lin
spellingShingle Jeffrey M. Ryckman
Bradley N. Reames
Kelsey A. Klute
William A. Hall
Michael J. Baine
May Abdel-Wahab
Chi Lin
The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?
Clinical and Translational Radiation Oncology
Pancreatic cancer
Stereotactic body radiotherapy
Total neoadjuvant therapy
author_facet Jeffrey M. Ryckman
Bradley N. Reames
Kelsey A. Klute
William A. Hall
Michael J. Baine
May Abdel-Wahab
Chi Lin
author_sort Jeffrey M. Ryckman
title The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?
title_short The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?
title_full The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?
title_fullStr The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?
title_full_unstemmed The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?
title_sort timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: is it time for change?
publisher Elsevier
series Clinical and Translational Radiation Oncology
issn 2405-6308
publishDate 2021-05-01
description Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes.
topic Pancreatic cancer
Stereotactic body radiotherapy
Total neoadjuvant therapy
url http://www.sciencedirect.com/science/article/pii/S2405630821000392
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