Progress of retinal organoids in treatment of retinal degenerative diseases
Retinal degeneration is the primary cause of visual impairment and blindness. However, in advanced stage of the disease, the majority or all photoreceptors are lost, effective therapeutics has not been established. In recent years, a large number of studies have provided new ways for the replacement...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2019-05-01
|
Series: | Guoji Yanke Zazhi |
Subjects: | |
Online Access: | http://ies.ijo.cn/cn_publish/2019/5/201905014.pdf |
id |
doaj-d8c22882d30d49f3bb28da3942bda426 |
---|---|
record_format |
Article |
spelling |
doaj-d8c22882d30d49f3bb28da3942bda4262020-11-24T23:07:40ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-05-0119577177410.3980/j.issn.1672-5123.2019.5.14Progress of retinal organoids in treatment of retinal degenerative diseasesHui-Yu Xi0Xi-Ying Mao1Jie Sun2Song-Tao Yuan3Qing-Huai Liu4Department of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaRetinal degeneration is the primary cause of visual impairment and blindness. However, in advanced stage of the disease, the majority or all photoreceptors are lost, effective therapeutics has not been established. In recent years, a large number of studies have provided new ways for the replacement of photoreceptors and three-dimensional retinal culture has emerged to produce retinal photoreceptors and tissues of both fetal mouse and human, providing the cell source of photoreceptors replacement therapy for treating retinal degenerative diseases. This review focuses on the development of three-dimensional retinal culture techniques and photoreceptors transplantation experiments, and the existing application strategies and limitations of retinal organoids in the replacement therapy of retinal degeneration, which provide a theoretical reference for the optimization of 3D retina in photoreceptors replacement therapy.http://ies.ijo.cn/cn_publish/2019/5/201905014.pdfretinal organoidsphotoreceptorstransplantationretinal degenerative diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui-Yu Xi Xi-Ying Mao Jie Sun Song-Tao Yuan Qing-Huai Liu |
spellingShingle |
Hui-Yu Xi Xi-Ying Mao Jie Sun Song-Tao Yuan Qing-Huai Liu Progress of retinal organoids in treatment of retinal degenerative diseases Guoji Yanke Zazhi retinal organoids photoreceptors transplantation retinal degenerative diseases |
author_facet |
Hui-Yu Xi Xi-Ying Mao Jie Sun Song-Tao Yuan Qing-Huai Liu |
author_sort |
Hui-Yu Xi |
title |
Progress of retinal organoids in treatment of retinal degenerative diseases |
title_short |
Progress of retinal organoids in treatment of retinal degenerative diseases |
title_full |
Progress of retinal organoids in treatment of retinal degenerative diseases |
title_fullStr |
Progress of retinal organoids in treatment of retinal degenerative diseases |
title_full_unstemmed |
Progress of retinal organoids in treatment of retinal degenerative diseases |
title_sort |
progress of retinal organoids in treatment of retinal degenerative diseases |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2019-05-01 |
description |
Retinal degeneration is the primary cause of visual impairment and blindness. However, in advanced stage of the disease, the majority or all photoreceptors are lost, effective therapeutics has not been established. In recent years, a large number of studies have provided new ways for the replacement of photoreceptors and three-dimensional retinal culture has emerged to produce retinal photoreceptors and tissues of both fetal mouse and human, providing the cell source of photoreceptors replacement therapy for treating retinal degenerative diseases. This review focuses on the development of three-dimensional retinal culture techniques and photoreceptors transplantation experiments, and the existing application strategies and limitations of retinal organoids in the replacement therapy of retinal degeneration, which provide a theoretical reference for the optimization of 3D retina in photoreceptors replacement therapy. |
topic |
retinal organoids photoreceptors transplantation retinal degenerative diseases |
url |
http://ies.ijo.cn/cn_publish/2019/5/201905014.pdf |
work_keys_str_mv |
AT huiyuxi progressofretinalorganoidsintreatmentofretinaldegenerativediseases AT xiyingmao progressofretinalorganoidsintreatmentofretinaldegenerativediseases AT jiesun progressofretinalorganoidsintreatmentofretinaldegenerativediseases AT songtaoyuan progressofretinalorganoidsintreatmentofretinaldegenerativediseases AT qinghuailiu progressofretinalorganoidsintreatmentofretinaldegenerativediseases |
_version_ |
1725617655271915520 |