Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis
Abstract Background Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This study aimed to evaluate the relation between serum OPG, RANKL concentration...
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doaj-d8c8b953e8d54d8293cc8808921017192020-11-25T01:05:48ZengBMCBMC Nephrology1471-23692018-07-011911710.1186/s12882-018-0960-zAssociation between low bone mass and the serum RANKL and OPG in patients with nephrolithiasisAsieh Mansour0Maryam Aboeerad1Mostafa Qorbani2Amir Pejman Hashemi Taheri3Mohamad Pajouhi4Abbas Ali Keshtkar5Bagher Larijani6Mohammad Reza Mohajeri-Tehrani7Mohammad Reza Ganji8Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesRadiology department, Shariati hospital, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDepartment of Health Science Education Development, School of Public Health, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesNephrology Research Center, Shariati Hospital, Tehran University of Medical SciencesAbstract Background Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This study aimed to evaluate the relation between serum OPG, RANKL concentration, and bone mineral density (BMD) in patients with kidney stone disease. Methods Forty-four nephrolithiasis patients with either low bone mass or normal BMD (considered control group) were enrolled in this study. BMD was measured at lumbar spine (L1-L4) and femoral neck by dual-energy X-ray absorptiometry (DEXA). The serum OPG and RANKL were determined using the ELISA method. Results The median levels of serum OPG were significantly higher in nephrolithiasis patients with low bone mass compared to the nephrolithiasis patients with normal BMD (3.9 pmol/l versus 3.1 pmol/l; P = 0.03), respectively. Negative correlation was detected between bone densities of femoral neck and OPG in patients with nephrolithiasis (r = −.0344, P = 0.02). Conclusion The present study showed that high serum fasting OPG levels may be indicative of femoral neck BMD in patients with nephrolithiasis.http://link.springer.com/article/10.1186/s12882-018-0960-zLow bone massOsteopeniaOsteoporosisBMDOPGRANKL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Asieh Mansour Maryam Aboeerad Mostafa Qorbani Amir Pejman Hashemi Taheri Mohamad Pajouhi Abbas Ali Keshtkar Bagher Larijani Mohammad Reza Mohajeri-Tehrani Mohammad Reza Ganji |
spellingShingle |
Asieh Mansour Maryam Aboeerad Mostafa Qorbani Amir Pejman Hashemi Taheri Mohamad Pajouhi Abbas Ali Keshtkar Bagher Larijani Mohammad Reza Mohajeri-Tehrani Mohammad Reza Ganji Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis BMC Nephrology Low bone mass Osteopenia Osteoporosis BMD OPG RANKL |
author_facet |
Asieh Mansour Maryam Aboeerad Mostafa Qorbani Amir Pejman Hashemi Taheri Mohamad Pajouhi Abbas Ali Keshtkar Bagher Larijani Mohammad Reza Mohajeri-Tehrani Mohammad Reza Ganji |
author_sort |
Asieh Mansour |
title |
Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis |
title_short |
Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis |
title_full |
Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis |
title_fullStr |
Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis |
title_full_unstemmed |
Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis |
title_sort |
association between low bone mass and the serum rankl and opg in patients with nephrolithiasis |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2018-07-01 |
description |
Abstract Background Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This study aimed to evaluate the relation between serum OPG, RANKL concentration, and bone mineral density (BMD) in patients with kidney stone disease. Methods Forty-four nephrolithiasis patients with either low bone mass or normal BMD (considered control group) were enrolled in this study. BMD was measured at lumbar spine (L1-L4) and femoral neck by dual-energy X-ray absorptiometry (DEXA). The serum OPG and RANKL were determined using the ELISA method. Results The median levels of serum OPG were significantly higher in nephrolithiasis patients with low bone mass compared to the nephrolithiasis patients with normal BMD (3.9 pmol/l versus 3.1 pmol/l; P = 0.03), respectively. Negative correlation was detected between bone densities of femoral neck and OPG in patients with nephrolithiasis (r = −.0344, P = 0.02). Conclusion The present study showed that high serum fasting OPG levels may be indicative of femoral neck BMD in patients with nephrolithiasis. |
topic |
Low bone mass Osteopenia Osteoporosis BMD OPG RANKL |
url |
http://link.springer.com/article/10.1186/s12882-018-0960-z |
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