Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4...

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Main Authors: Shuangqing Zhang, Yan Zhang, Ning Peng, Haibo Zhang, Juan Yao, Zhihong Li, Liegang Liu
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2014/217142
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spelling doaj-d8d49798f88e4c8cb4bd2aa64e2f275c2020-11-24T21:45:15ZengHindawi LimitedThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/217142217142Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in RatsShuangqing Zhang0Yan Zhang1Ning Peng2Haibo Zhang3Juan Yao4Zhihong Li5Liegang Liu6Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaZinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.http://dx.doi.org/10.1155/2014/217142
collection DOAJ
language English
format Article
sources DOAJ
author Shuangqing Zhang
Yan Zhang
Ning Peng
Haibo Zhang
Juan Yao
Zhihong Li
Liegang Liu
spellingShingle Shuangqing Zhang
Yan Zhang
Ning Peng
Haibo Zhang
Juan Yao
Zhihong Li
Liegang Liu
Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
The Scientific World Journal
author_facet Shuangqing Zhang
Yan Zhang
Ning Peng
Haibo Zhang
Juan Yao
Zhihong Li
Liegang Liu
author_sort Shuangqing Zhang
title Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_short Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_full Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_fullStr Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_full_unstemmed Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_sort pharmacokinetics and biodistribution of zinc-enriched yeast in rats
publisher Hindawi Limited
series The Scientific World Journal
issn 2356-6140
1537-744X
publishDate 2014-01-01
description Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.
url http://dx.doi.org/10.1155/2014/217142
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