Styrylpyrazoles: Properties, Synthesis and Transformations

The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole d...

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Main Authors:	Pedro M. O. Gomes, Pedro M. S. Ouro, Artur M. S. Silva, Vera L. M. Silva
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Molecules
Subjects:	pyrazoles styrylpyrazoles biological activity organic synthesis reactivity
Online Access:	https://www.mdpi.com/1420-3049/25/24/5886

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spelling	doaj-d8d72eb0020f42f8b69cdefdc95197372020-12-13T00:01:41ZengMDPI AGMolecules1420-30492020-12-01255886588610.3390/molecules25245886Styrylpyrazoles: Properties, Synthesis and TransformationsPedro M. O. Gomes0Pedro M. S. Ouro1Artur M. S. Silva2Vera L. M. Silva3LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalThe pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound.https://www.mdpi.com/1420-3049/25/24/5886pyrazolesstyrylpyrazolesbiological activityorganic synthesisreactivity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pedro M. O. Gomes Pedro M. S. Ouro Artur M. S. Silva Vera L. M. Silva
spellingShingle	Pedro M. O. Gomes Pedro M. S. Ouro Artur M. S. Silva Vera L. M. Silva Styrylpyrazoles: Properties, Synthesis and Transformations Molecules pyrazoles styrylpyrazoles biological activity organic synthesis reactivity
author_facet	Pedro M. O. Gomes Pedro M. S. Ouro Artur M. S. Silva Vera L. M. Silva
author_sort	Pedro M. O. Gomes
title	Styrylpyrazoles: Properties, Synthesis and Transformations
title_short	Styrylpyrazoles: Properties, Synthesis and Transformations
title_full	Styrylpyrazoles: Properties, Synthesis and Transformations
title_fullStr	Styrylpyrazoles: Properties, Synthesis and Transformations
title_full_unstemmed	Styrylpyrazoles: Properties, Synthesis and Transformations
title_sort	styrylpyrazoles: properties, synthesis and transformations
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2020-12-01
description	The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound.
topic	pyrazoles styrylpyrazoles biological activity organic synthesis reactivity
url	https://www.mdpi.com/1420-3049/25/24/5886
work_keys_str_mv	AT pedromogomes styrylpyrazolespropertiessynthesisandtransformations AT pedromsouro styrylpyrazolespropertiessynthesisandtransformations AT arturmssilva styrylpyrazolespropertiessynthesisandtransformations AT veralmsilva styrylpyrazolespropertiessynthesisandtransformations
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Styrylpyrazoles: Properties, Synthesis and Transformations

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