Cancer-associated adipocytes as immunomodulators in cancer

Cancer-associated adipocytes as immunomodulators in cancer

Abstract Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the...

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Main Authors: Qi Wu, Bei Li, Juanjuan Li, Si Sun, Jingping Yuan, Shengrong Sun
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Biomarker Research
Subjects:
Cancer-associated adipocytes
Tumor
Immune cells
Metabolism
Online Access:https://doi.org/10.1186/s40364-020-00257-6
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spelling doaj-d8dc19729d8f4e85bae517572c1ca4102021-01-10T12:22:38ZengBMCBiomarker Research2050-77712021-01-019112110.1186/s40364-020-00257-6Cancer-associated adipocytes as immunomodulators in cancerQi Wu0Bei Li1Juanjuan Li2Si Sun3Jingping Yuan4Shengrong Sun5Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityAbstract Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary interplay among CAAs, the immune response and cancer with a focus on the mechanistic aspects of these relationships. Finally, unifying our understanding of CAAs with the immune cell function may be an effective method to enhance the efficacy of immunotherapeutic and conventional treatments.https://doi.org/10.1186/s40364-020-00257-6Cancer-associated adipocytesTumorImmune cellsMetabolism
collection DOAJ
language English
format Article
sources DOAJ
author Qi Wu
Bei Li
Juanjuan Li
Si Sun
Jingping Yuan
Shengrong Sun
spellingShingle Qi Wu
Bei Li
Juanjuan Li
Si Sun
Jingping Yuan
Shengrong Sun
Cancer-associated adipocytes as immunomodulators in cancer
Biomarker Research
Cancer-associated adipocytes
Tumor
Immune cells
Metabolism
author_facet Qi Wu
Bei Li
Juanjuan Li
Si Sun
Jingping Yuan
Shengrong Sun
author_sort Qi Wu
title Cancer-associated adipocytes as immunomodulators in cancer
title_short Cancer-associated adipocytes as immunomodulators in cancer
title_full Cancer-associated adipocytes as immunomodulators in cancer
title_fullStr Cancer-associated adipocytes as immunomodulators in cancer
title_full_unstemmed Cancer-associated adipocytes as immunomodulators in cancer
title_sort cancer-associated adipocytes as immunomodulators in cancer
publisher BMC
series Biomarker Research
issn 2050-7771
publishDate 2021-01-01
description Abstract Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary interplay among CAAs, the immune response and cancer with a focus on the mechanistic aspects of these relationships. Finally, unifying our understanding of CAAs with the immune cell function may be an effective method to enhance the efficacy of immunotherapeutic and conventional treatments.
topic Cancer-associated adipocytes
Tumor
Immune cells
Metabolism
url https://doi.org/10.1186/s40364-020-00257-6
work_keys_str_mv AT qiwu cancerassociatedadipocytesasimmunomodulatorsincancer
AT beili cancerassociatedadipocytesasimmunomodulatorsincancer
AT juanjuanli cancerassociatedadipocytesasimmunomodulatorsincancer
AT sisun cancerassociatedadipocytesasimmunomodulatorsincancer
AT jingpingyuan cancerassociatedadipocytesasimmunomodulatorsincancer
AT shengrongsun cancerassociatedadipocytesasimmunomodulatorsincancer
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