αvβ3 Integrin induces partial EMT independent of TGF-β signaling

αvβ3 Integrin induces partial EMT independent of TGF-β signaling

Kariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, s...

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Main Authors: Yoshinobu Kariya, Midori Oyama, Takato Suzuki, Yukiko Kariya
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02003-6
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spelling doaj-d8dded810a1f4dd2ba943cbec8b2bb052021-04-25T11:29:40ZengNature Publishing GroupCommunications Biology2399-36422021-04-014111110.1038/s42003-021-02003-6αvβ3 Integrin induces partial EMT independent of TGF-β signalingYoshinobu Kariya0Midori Oyama1Takato Suzuki2Yukiko Kariya3Department of Biochemistry, Fukushima Medical University School of MedicineDepartment of Biochemistry, Fukushima Medical University School of MedicineLaboratory Animal Research Center, Fukushima Medical University School of MedicineDepartment of Biochemistry, Fukushima Medical University School of MedicineKariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, stemness and metastatic capacity.https://doi.org/10.1038/s42003-021-02003-6
collection DOAJ
language English
format Article
sources DOAJ
author Yoshinobu Kariya
Midori Oyama
Takato Suzuki
Yukiko Kariya
spellingShingle Yoshinobu Kariya
Midori Oyama
Takato Suzuki
Yukiko Kariya
αvβ3 Integrin induces partial EMT independent of TGF-β signaling
Communications Biology
author_facet Yoshinobu Kariya
Midori Oyama
Takato Suzuki
Yukiko Kariya
author_sort Yoshinobu Kariya
title αvβ3 Integrin induces partial EMT independent of TGF-β signaling
title_short αvβ3 Integrin induces partial EMT independent of TGF-β signaling
title_full αvβ3 Integrin induces partial EMT independent of TGF-β signaling
title_fullStr αvβ3 Integrin induces partial EMT independent of TGF-β signaling
title_full_unstemmed αvβ3 Integrin induces partial EMT independent of TGF-β signaling
title_sort αvβ3 integrin induces partial emt independent of tgf-β signaling
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-04-01
description Kariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, stemness and metastatic capacity.
url https://doi.org/10.1038/s42003-021-02003-6
work_keys_str_mv AT yoshinobukariya avb3integrininducespartialemtindependentoftgfbsignaling
AT midorioyama avb3integrininducespartialemtindependentoftgfbsignaling
AT takatosuzuki avb3integrininducespartialemtindependentoftgfbsignaling
AT yukikokariya avb3integrininducespartialemtindependentoftgfbsignaling
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