αvβ3 Integrin induces partial EMT independent of TGF-β signaling
Kariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, s...
Main Authors: | Yoshinobu Kariya, Midori Oyama, Takato Suzuki, Yukiko Kariya |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-021-02003-6 |
Similar Items
-
Roles of Integrin α6β4 Glycosylation in Cancer
by: Yoshinobu Kariya, et al.
Published: (2017-07-01) -
Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility
by: Yoshinobu Kariya, et al.
Published: (2021-09-01) -
TGFβ<sub>1 </sub>signaling via α<sub>V</sub>β<sub>6 </sub>integrin
by: Sclabas Guido M, et al.
Published: (2003-08-01) -
Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells.
by: Seiji Mori, et al.
Published: (2015-01-01) -
Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells
by: Mark S. Filla, et al.
Published: (2021-07-01)