Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy

MYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence, development, invasion and metastasis in many kinds of solid tumors and hematologic neoplasms. In tumors, the low expression and the short half-life of Myc are reversed, cause tumorigenesis. And proteins that directly...

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Main Authors:	Yihui Zhou, Xiaomeng Gao, Meng Yuan, Bo Yang, Qiaojun He, Ji Cao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Pharmacology
Subjects:	MYC cancer therapy interaction protein transcriptional regulation post-translational modification inhibitors
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.748852/full

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spelling	doaj-d8de40555f964e24ac7fba8c0a7a40ab2021-09-29T05:48:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-09-011210.3389/fphar.2021.748852748852Targeting Myc Interacting Proteins as a Winding Path in Cancer TherapyYihui Zhou0Xiaomeng Gao1Meng Yuan2Bo Yang3Bo Yang4Qiaojun He5Qiaojun He6Qiaojun He7Ji Cao8Ji Cao9Ji Cao10Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaCancer Center of Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaThe Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaCancer Center of Zhejiang University, Hangzhou, ChinaThe Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaCancer Center of Zhejiang University, Hangzhou, ChinaThe Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, ChinaMYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence, development, invasion and metastasis in many kinds of solid tumors and hematologic neoplasms. In tumors, the low expression and the short half-life of Myc are reversed, cause tumorigenesis. And proteins that directly interact with different Myc domains have exerted a significant impact in the process of Myc-driven carcinogenesis. Apart from affecting the transcription of Myc target genes, Myc interaction proteins also regulate the stability of Myc through acetylation, methylation, phosphorylation and other post-translational modifications, as well as competitive combination with Myc. In this review, we summarize a series of Myc interacting proteins and recent advances in the related inhibitors, hoping that can provide new opportunities for Myc-driven cancer treatment.https://www.frontiersin.org/articles/10.3389/fphar.2021.748852/fullMYCcancer therapyinteraction proteintranscriptional regulationpost-translational modificationinhibitors
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yihui Zhou Xiaomeng Gao Meng Yuan Bo Yang Bo Yang Qiaojun He Qiaojun He Qiaojun He Ji Cao Ji Cao Ji Cao
spellingShingle	Yihui Zhou Xiaomeng Gao Meng Yuan Bo Yang Bo Yang Qiaojun He Qiaojun He Qiaojun He Ji Cao Ji Cao Ji Cao Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy Frontiers in Pharmacology MYC cancer therapy interaction protein transcriptional regulation post-translational modification inhibitors
author_facet	Yihui Zhou Xiaomeng Gao Meng Yuan Bo Yang Bo Yang Qiaojun He Qiaojun He Qiaojun He Ji Cao Ji Cao Ji Cao
author_sort	Yihui Zhou
title	Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy
title_short	Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy
title_full	Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy
title_fullStr	Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy
title_full_unstemmed	Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy
title_sort	targeting myc interacting proteins as a winding path in cancer therapy
publisher	Frontiers Media S.A.
series	Frontiers in Pharmacology
issn	1663-9812
publishDate	2021-09-01
description	MYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence, development, invasion and metastasis in many kinds of solid tumors and hematologic neoplasms. In tumors, the low expression and the short half-life of Myc are reversed, cause tumorigenesis. And proteins that directly interact with different Myc domains have exerted a significant impact in the process of Myc-driven carcinogenesis. Apart from affecting the transcription of Myc target genes, Myc interaction proteins also regulate the stability of Myc through acetylation, methylation, phosphorylation and other post-translational modifications, as well as competitive combination with Myc. In this review, we summarize a series of Myc interacting proteins and recent advances in the related inhibitors, hoping that can provide new opportunities for Myc-driven cancer treatment.
topic	MYC cancer therapy interaction protein transcriptional regulation post-translational modification inhibitors
url	https://www.frontiersin.org/articles/10.3389/fphar.2021.748852/full
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Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy

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